Current And Future Outlook Of Loaded Components In Hydrogel Composites For The Treatment Of Chronic Diabetic Ulcers
February 2023
in “
Frontiers in Bioengineering and Biotechnology
”
TLDR Hydrogel composites are promising for treating chronic diabetic ulcers due to their versatility and effectiveness.
The document reviewed the use of hydrogel composites loaded with various components to treat chronic diabetic ulcers, addressing challenges like impaired angiogenesis, inflammation, infections, oxidative stress, and neuropathy. It highlighted innovative hydrogels with polymers, stem cells, metal ions, and plant extracts that promoted angiogenesis, reduced inflammation, and combated infections. Conductive and antioxidant hydrogels showed high bactericidal rates and reduced oxidative stress, while nerve regeneration was supported by specific pathways. The role of stem cell-derived exosomes and chelating agents like deferoxamine was discussed for their regenerative and antibacterial effects. The study emphasized the potential of "all-in-one" hydrogels combining multiple components to enhance wound healing, suggesting future research on dual-sensitivity systems for sequential compound delivery.
