Living Microecological Hydrogels for Wound Healing
May 2023
in “
Science Advances
”
Studysummary In this study, the researchers developed a living microecological hydrogel containing <i>Chlorella</i> and <i>Bacillus subtilis</i> that showed potential in promoting the healing of infected diabetic wounds by providing continuous oxygen delivery and anti-infective properties.
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The study introduces a living microecological hydrogel (LMH) designed to enhance the healing of chronic wounds by addressing infections and hypoxia. The LMH incorporates Chlorella and Bacillus subtilis, which work together to deliver continuous oxygen and combat infections. It remains liquid at low temperatures and solidifies upon application to wounds. In a diabetic rat model with S. aureus-infected wounds, LMH-treated wounds showed faster healing, reduced inflammation, and increased collagen deposition compared to controls. The hydrogel's ability to release oxygen and its antibacterial properties were key factors in its effectiveness, making it a promising treatment for chronic wounds.
