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The engineered skin substitute helped grow skin with hair on mice.

Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.

Box A of HMGB1 can improve stem cell function, aiding anti-aging therapy.

New treatments for hair loss, fertility, and wound healing are being explored.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

Skin and hair can regenerate after injury due to changes in gene activity, with potential links to how cancer spreads. Future research should focus on how new hair follicles form and the processes that trigger their creation.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

The vitamin D receptor is essential for skin stem cells to grow, move, and become different cell types needed for skin healing.

Understanding keratinization is crucial for treating skin conditions like ichthyoses and psoriasis.

Vitamin D receptor helps control hair growth genes in skin cells.

Lack of Ctip2 in skin cells delays wound healing and disrupts hair follicle stem cell markers in mice.

Melatonin treatment helps improve skin health in postmenopausal rats.

Noggin overexpression delays eyelid opening by affecting cell death and skin cell development.

Dermal papillae cells, important for hair growth, come from multiple cell lines and can be formed by skin cells, regardless of their origin or hair cycle phase. These cells rarely divide, but their ability to shape tissue may contribute to their efficiency in inducing hair growth.

MMP-9 is essential for proper hair canal formation.

Hair keratins evolved from ancient proteins, diversifying through gene changes, crucial for forming claws and later hair in mammals.

A specific group of slow-growing stem cells marked by Thy1 is crucial for skin maintenance and healing in mice.

Skin fat cells help with skin balance, hair growth, and healing wounds.

Loss of keratin K2 causes skin problems and inflammation.

Mice lacking a key DNA methylation enzyme in skin cells have a lower chance of activating stem cells necessary for hair growth, leading to progressive hair loss.

The enzymes Tet2 and Tet3 are important for skin cell development and hair growth.

Mice with too much Claudin-6 have skin barrier problems and abnormal hair growth.

Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.

ADAM 10 and ADAM 12 proteins are involved in different stages of hair growth and could be targets for treating hair disorders.

Tcf3 helps cells move and heal wounds by controlling lipocalin 2.

EGFR helps control how hair grows and forms without needing p53 protein.

Hair follicles in mutant mice self-organize into ordered patterns within a week.

Aging in hair follicle stem cells leads to hair graying, thinning, and loss.

Disrupting β-catenin signaling in certain cells causes anorectal malformations.