13 citations
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May 1998 in “The Journal of Clinical Endocrinology & Metabolism” This study found that hCG decreased 5α-reductase and androgen receptor levels in skin samples from women in vitro, suggesting that human skin responds to LH/hCG treatment.
July 2023 in “Journal of the ASEAN Federation of Endocrine Societies” In this study of a postmenopausal woman with hyperandrogenism, GnRH agonist treatment significantly reduced testosterone levels, suggesting the androgen excess was ovarian in origin and indicating the potential of using GnRH agonists as a conservative treatment option when surgery is not feasible.
1 citations
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July 2016 in “Mağallaẗ Kulliyyaẗ al-ṭibb Baġdād” This study found that women with polycystic ovary syndrome had significantly higher levels of prostate-specific antigen, which positively correlated with testosterone levels, the LH/FSH ratio, and hirsutism severity.
October 2024 in “Journal of the Endocrine Society” This case report details a diagnostic challenge in a postmenopausal woman with severe hyperandrogenism where distinguishing between adrenal and ovarian causes was complicated by elevated 17-OH Progesterone and asymmetric ovarian enlargement; pending surgical pathology is expected to guide further management.
2 citations
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November 2019 in “Case reports in women's health” In this study, two women with hyperandrogenic symptoms were found to have ovarian Leydig cell tumors after selective ovarian venous sampling and salpingo-oophorectomy, leading to a decline in testosterone levels post-surgery.
October 2022 in “Miscellaneous” This study documented a case of a 57-year-old woman with postmenopausal virilism due to a Sertoli-Leydig cell tumor, which improved after surgical treatment.
5 citations
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October 2014 in “Gynecological Endocrinology” This case study describes a 15-year-old girl with a Sertoli–Leydig cell tumor who showed high androgen levels and steroidogenic responses similar to patients with polycystic ovary syndrome before surgery.
53 citations
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January 1985 in “Acta obstetricia et gynecologica Scandinavica” This study found that an 8-month treatment with a low-dose oral contraceptive significantly reduced testosterone levels and hair growth in women with polycystic ovary syndrome and hirsutism, with minimal side effects.
June 2025 in “Journal of Kufa for Chemical Sciences” In this study, researchers observed increased hormone levels such as testosterone and LH in both obese and non-obese women with Polycystic Ovary Syndrome, but concluded that the enzyme 3βHSD shows poor diagnostic value for PCOS compared to healthy women.
28 citations
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September 2017 in “Gynecological Endocrinology” This study found that women with polycystic ovary syndrome had significantly higher serum and intrafollicular levels of anti-Müllerian hormone compared to normovulatory women, indicating a potential marker for ovarian hyperstimulation syndrome risk.
March 2016 in “Journal of the Turkish-German Gynecological Association” The woman likely has a hormonal imbalance causing excessive hair growth.
December 2021 in “Aegean journal of obstetrics and gynecology” This case report highlights a rare instance of postmenopausal virilization in a 71-year-old woman due to coexisting ovarian hilus cell hyperplasia and a Sertoli-Leydig cell tumor.
November 2021 in “Khyber Medical University Journal” This case report highlights that uncommon ovarian tumors like sclerosal stromal tumors can cause hirsutism and virilization in postmenopausal women and lead to androgen secretion, despite typically being hormonally inactive.
October 2024 in “Journal of the Endocrine Society” This case report highlights the challenge of differentiating between non-classical adrenal hyperplasia and steroid cell tumors of the ovary in a patient presenting with hyperandrogenism.
In this report, a 22-year-old woman with congenital adrenal hyperplasia due to 21-hydroxylase deficiency underwent treatment with hydrocortisone and spironolactone, followed by feminization surgery, which subsequently led to the development of secondary sexual characteristics and regular menstruation.
January 2023 in “Case Reports in Obstetrics and Gynecology” This case report highlights the need for early diagnosis and treatment of ovarian hyperthecosis to enhance the quality of life and health outcomes for affected patients.
July 2023 in “Endocrinology, diabetes & metabolism case reports” This case report involved a premenopausal woman with rapidly progressing virilizing symptoms caused by a rare sertoliform endometrioid carcinoma of the ovary. Following surgical intervention, her symptoms improved, highlighting the importance of recognizing virilizing symptoms as potential indicators of low-grade ovarian malignancies in similar cases.
19 citations
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October 2019 in “Clinical and Experimental Dermatology” This study found that spironolactone significantly reduced pain, lesion count, and disease severity in patients with hidradenitis suppurativa, as reported in multiple patient cohorts.
November 2023 in “JCEM Case Reports” In this case report, a 55-year-old postmenopausal woman was diagnosed with ovarian hyperthecosis as the cause of her hyperandrogenism after detailed hormonal and imaging investigations, which was successfully treated with bilateral salpingo-oophorectomy, leading to symptom improvement and normalized testosterone levels.
September 2021 in “Journal of pharmaceutical research international” This study found that hirsutism patients had a strong correlation with polycystic ovary syndrome and elevated levels of certain hormones, such as 17-OHP and serum testosterone.
November 2022 in “Journal of the Endocrine Society” This case report highlights the diagnostic challenge of identifying androgen-secreting ovarian Leydig cell tumors in postmenopausal women when imaging fails to reveal masses, emphasizing the usefulness of ovarian vein sampling for localization.
216 citations
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November 1999 in “Fertility and Sterility” This study found that a basal 17-hydroxyprogesterone level is effective for screening nonclassic adrenal hyperplasia in women, with a 4 ng/mL cutoff providing high specificity and positive predictive value.
April 2025 in “The Obstetrician & Gynaecologist” This study highlights that hirsutism in women, most commonly caused by polycystic ovary syndrome, should be evaluated with tools like the Ferriman–Gallwey score and total testosterone measurements, and managed using methods like hair removal and combined oral contraceptives when fertility preservation is not a priority.
9 citations
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May 2017 in “Gynecological Endocrinology” In this study, transvaginal hydrolaparoscopy ovarian drilling in CC-resistant women with PCOS significantly improved ovulation and pregnancy rates over a six-month period, with 82.9% ovulating and a 70.1% pregnancy rate by the end of the study.
7 citations
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September 2014 in “Journal of Obstetrics and Gynaecology Research” This study found that the ovarian stromal area to total ovarian area ratio alone is not a strong predictor of biochemical hyperandrogenism in Thai women with PCOS, but combining it with clinical hyperandrogenism improves prediction.
30 citations
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June 2015 in “Dermatologic Surgery” This abstract does not provide any new research findings or results.
April 2021 in “Journal of Investigative Dermatology” This trial found that intradermal injections of the Hair Stimulating Complex were well-tolerated and effectively stimulated hair growth and prevented hair loss in male pattern baldness participants over 18 weeks.
71 citations
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June 2006 in “Human Reproduction” This study found that in young Taiwanese women with PCOS, low sex hormone-binding globulin levels were associated with low HDL cholesterol levels, independent of insulin resistance and obesity.
In this study, researchers evaluated hirsutism in young females aged 18-24 using the modified Ferriman-Gallwey scoring system, finding that 52% showed mild to moderate-to-severe symptoms, often linked to menstrual irregularities and underlying endocrine disorders like polycystic ovary syndrome and thyroid issues.
1 citations
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March 2005 in “Zentralblatt für Gynäkologie” This case report describes a postmenopausal woman with hirsutism and androgenetic alopecia, where imaging ruled out malignancy and selective venous sampling indicated increased testosterone from the right adrenal vein, leading to a recommendation for right adrenalectomy and oophorectomy.