Effect of 3-Beta Hydroxysteroid Dehydrogenase on Serum Testosterone Level in Obese Women With Polycystic Ovary Syndrome
June 2025
in “
Journal of Kufa for Chemical Sciences
”
Studysummary In this study, researchers observed increased hormone levels such as testosterone and LH in both obese and non-obese women with Polycystic Ovary Syndrome, but concluded that the enzyme 3βHSD shows poor diagnostic value for PCOS compared to healthy women.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study investigated the role of 3-Beta Hydroxysteroid Dehydrogenase (3βHSD2) in serum testosterone levels among 90 women aged 18 to 40, divided into three groups: 30 obese women with PCOS, 30 non-obese women with PCOS, and 30 healthy controls. Results showed increased serum levels of testosterone, LH, LH:FSH, and prolactin, with decreased levels of 3βHSD2 and FSH in women with PCOS compared to controls. The study concluded that 3βHSD2 has poor diagnostic value for PCOS, despite its involvement in the condition's pathogenesis.
