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    Glossary Homeobox Genes

    regulatory genes controlling body plan and organ development

    Homeobox genes, often referred to as Hox genes, are a group of regulatory genes that play a crucial role in determining the body plan and the formation of tissues and organs during early embryonic development. They contain a specific DNA sequence called the homeobox, which encodes a protein domain (the homeodomain) that can bind to DNA and regulate the expression of other genes. This precise regulation ensures that body structures form in the correct locations.

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    Research 30 of 437

    1. Epidermal Dysplasia and Abnormal Hair Follicles in Transgenic Mice Overexpressing Homeobox Gene MSX-2 Journal of Investigative Dermatology · 1999 · 49 citations
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Altered Skin Wound Healing in Homeobox Gene Msx-2 Knockout Mice Wound Repair and Regeneration · 2008
    3. A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11 Genomics · 1989 · 49 citations
    4. Association between DNA Methylation in the Core Promoter Region of the CUT-like Homeobox 1 (CUX1) Gene and Lambskin Pattern in Hu Sheep Genes · 2023 · 1 citations
    5. Structure and expression of the ovine Hoxc-13 gene Gene · 2003 · 12 citations
    6. Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora Goats 2023
    7. Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora goats Research Square (Research Square) · 2022
    8. PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis Stem Cell Research & Therapy · 2019 · 26 citations
    9. Deletion of adipocyte Sine Oculis Homeobox Homolog 1 prevents lipolysis and attenuates skin fibrosis 2024
    10. Molecular histology in skin appendage morphogenesis Microscopy Research and Technique · 1997 · 57 citations
    11. Multiple Roles of Integrin-Linked Kinase in Epidermal Development, Maturation and Pigmentation Revealed by Molecular Profiling PLOS ONE · 2012 · 9 citations
    12. <i>Hoxc13</i> mutant mice lack external hair Genes & Development · 1998 · 245 citations
    13. Whole-genome resequencing to investigate the genetic diversity and the molecular basis underlying key economic traits in indigenous sheep breeds adapted to hypoxic environments Frontiers in Veterinary Science · 2025 · 1 citations
    14. HOMEOBOX PROTEIN 24 mediates the conversion of indole‐3‐butyric acid to indole‐3‐acetic acid to promote root hair elongation New Phytologist · 2021 · 21 citations
    15. Gene expression patterns during palatal shelf fusion Journal of the American College of Surgeons · 2004
    16. Faculty Opinions recommendation of Modulation of phospholipid signaling by GLABRA2 in root-hair pattern formation. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2003
    17. Male infertility and genitourinary birth defects: there is more than meets the eye Fertility and Sterility · 2020 · 26 citations
    18. Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study Endocrine connections · 2019 · 8 citations
    19. SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair Nature Communications · 2019 · 87 citations
    20. Microarray analysis of androgenetic and senescent alopecia: Comparison of gene expression shows two distinct profiles Journal of Dermatological Science · 2013 · 27 citations
    21. Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia Journal of The American Academy of Dermatology · 2018 · 25 citations
    22. Seasonal Gene Expression Profile Responsible For Hair Follicle Development In Angora Goats Research Square (Research Square) · 2022 · 2 citations
    23. Large Scale Gene Expression Profiles of Regenerating Inner Ear Sensory Epithelia PLoS ONE · 2007 · 77 citations
    24. Risk factors for prostate cancer: a case-control study investigating selected key exposures and their interactions with predisposition genes Jurnal Natural (Faculty of Mathematics and Natural Science, Syiah Kuala University) · 2010
    25. Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats PLoS ONE · 2016 · 127 citations
    26. Expression Profiling Reveals Genes Involved in the Regulation of Wool Follicle Bulb Regression and Regeneration in Sheep International Journal of Molecular Sciences · 2015 · 19 citations
    27. Computational derivation of a molecular framework for hair follicle biology from disease genes Scientific Reports · 2017 · 4 citations
    28. Hoxc13 polyglycine repeat gain-of-function drives mammalian integument evolution by altering targeted genes and interactions Research Square · 2026
    29. A preliminary study of differentially expressed genes in expanded skin and normal skin: implications for adult skin regeneration Archives of Dermatological Research · 2011 · 16 citations
    30. Identification of potential key genes and pathways associated with the Pashmina fiber initiation using RNA-Seq and integrated bioinformatics analysis Scientific Reports · 2021 · 36 citations