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This phase II trial found that BI 2536 demonstrated limited antitumor activity across five solid tumor types, with no confirmed objective responses observed.

This review explores how microneedles can improve the delivery of dermatological treatments by bypassing the skin's outer barrier, discussing their potential use in managing skin diseases, cosmetic applications, and challenges related to clinical adoption.

This review article highlights recent advances in microneedle technology for wound healing and tissue regeneration, discussing various cargo types, structural designs, and fabrication methods, and suggesting guidelines for designing microneedle systems tailored to specific applications.

This review discusses hydrogel-forming microneedles for non-invasive drug delivery in dermatology and reports no new clinical results, emphasizing their promise in improving treatment adherence and patient comfort.

This review examines the potential of swellable microneedles in drug delivery and diagnostics, highlighting innovations and challenges in their use for chronic disease treatment, but noting that issues like physiological responsiveness and long-term stability still require research.

This review discusses the challenges of traditional phytochemical delivery methods and highlights the potential of microneedles to improve intra/transdermal delivery, reporting no new clinical results.

This study explored the potential of silk fibroin methacrylate hydrogel microneedles to deliver α-MSH directly to the epidermis in vitiligo patients, enhancing melanocyte protection and melanosome transfer, potentially offering a new treatment avenue for this challenging condition.

This study reviews the etiology and treatment of skin cancer, focusing on nanotechnology's role in addressing drug resistance and evaluating nanoparticles' potential to improve treatment outcomes, including overcoming multidrug resistance.

This study reviews how advancements in nanotechnology have improved food safety, nutrition delivery, and health interventions, but it also highlights the need for more research into safety evaluations and regulatory concerns.

This review discusses the role of exosomes in medical aesthetics, focusing on their mechanisms, production, and preservation, but reports no new clinical results and highlights barriers to their widespread application.

Salivary vitamin D and IL-6 could help diagnose and manage non-scarring alopecia.

This study summarizes the role and potential applications of stem cell exosomes in skin and bone healing, highlighting their regenerative capabilities and suggesting innovative delivery methods like nanoliposomes and hydrogels to improve bioavailability and therapeutic outcomes.

This paper reviews extraction methods for obtaining polysaccharides from brown macroalgae like Sargassum, highlighting their antiviral, antimicrobial, and antitumoral bioactivities in both in vivo and in vitro studies, while also discussing challenges in research and commercialization of Sargassum-based products.

This study highlights the clinical potential of microneedles as an innovative transdermal drug delivery system for treating various skin diseases with minimal pain and high patient compliance.

This study found that Epiprofin acts as a negative regulator of parathyroid hormone transcription, with potential implications for controlling PTH production in hyperparathyroidism.

This review indicates that various laser therapies, alone or combined with other treatments, show potential in improving hair density and treating androgenetic alopecia, but outcomes can vary, underscoring the importance of personalized treatment.

This study examined the effectiveness of peppermint essential oil formulated into a nanoliposome gel for enhancing hair growth, finding that this preparation increased hair growth in male Sprague Dawley rats without causing irritation, suggesting it may improve delivery of these active ingredients.

This study identified three hub genes—BMP4, POSTN, and WNT5A—that are closely associated with keloid fibroblast hyperplasia, suggesting they may serve as potential biomarkers for inhibiting this condition. Further research is necessary to fully understand their roles in keloid development.

This study highlights promising methods for converting food waste into valuable resources such as biogas, bioethanol, biodiesel, fertilizers, and antioxidants through processes like fermentation and anaerobic digestion, emphasizing the need for robust large-scale technologies to optimize this "waste to value" transformation.

This review highlights the use of microneedling devices and patches to deliver cosmetic agents through the skin, noting their applications in skin rejuvenation and safety considerations such as potential skin irritation and infection.

This review highlights the potential of microneedle technology in traditional Chinese medicine as a promising transdermal delivery system for skin diseases, showcasing improved efficacy and reduced side effects of TCM ingredients while discussing the challenges of its clinical application.

This review discusses recent advancements in microneedle technology for hair loss treatment, highlighting their ability to enhance drug delivery and improve hair follicle survival in transplantation, while also exploring their potential integration with tissue engineering to address regeneration challenges.

This review highlights the application of microneedle technology as a promising advancement in psoriasis management, focusing on its roles in enhanced transdermal drug delivery and minimally invasive biomarker monitoring, while also discussing current challenges and future research directions.

This study reported that a curcumin-zinc microneedle patch improved hair regrowth and wound healing in animal models, suggesting potential as a versatile treatment for hair loss.

Minoxidil helps hair regrowth in alopecia areata safely.

Minoxidil can help grow hair and make hair follicles bigger, but it can also cause side effects.

Minoxidil doesn't affect perifollicular lymphoid infiltration in alopecia areata patients.

This study found that androgenic alopecia is the strongest predictor of coronary artery disease in young men from Western India, followed by premature graying and obesity.

This perspective highlights evidence suggesting inflammation plays a significant role in male and female pattern hair loss, indicating that targeting inflammatory pathways may improve future therapeutic options.