68 citations,
January 2022 in “International Journal of Molecular Sciences” PCOS management includes lifestyle changes and medications, with ongoing research into repurposed drugs for better treatment options.
58 citations,
March 2011 in “Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere/Pflügers Archiv” Hormones and signaling pathways control sebaceous gland function and could help treat acne.
55 citations,
March 2010 in “Aging” Circadian clock genes are important for hair growth and may affect aging-related hair loss and graying.
50 citations,
May 2021 in “Frontiers in immunology” Certain immune cells contribute to skin autoimmune diseases, and some treatments can reverse hair loss in these conditions.
50 citations,
February 2013 in “BMC evolutionary biology” Cetaceans lost hair due to changes in the Hr and FGF5 genes.
49 citations,
June 2019 in “eLife” Ancient DNA blocks are still present in human genomes, possibly due to advantages they provide.
45 citations,
May 2019 in “International Immunology” The study concluded that immune cells attacking hair follicles cause hair loss in alopecia, with genetics and environment also playing a role, and highlighted the potential of certain treatments.
43 citations,
January 2016 in “Oxidative medicine and cellular longevity” THSG from a Chinese plant helps with aging and related diseases.
43 citations,
January 2016 in “Cellular physiology and biochemistry” Epidermal Growth Factor helps hair follicle cells grow and move by activating a specific cell signaling pathway.
39 citations,
October 2012 in “Familial cancer” New therapies for Birt–Hogg–Dubé syndrome are being developed based on understanding the FLCN gene's role.
38 citations,
December 2020 in “International journal of biochemistry & cell biology” Keratin proteins are essential for keeping the cells in the human colon healthy and stable.
38 citations,
April 2017 in “PLOS Genetics” GRHL3 is important for controlling gene activity in skin cells during different stages of their development.
36 citations,
October 2015 in “Cell reports” Gab1 protein is crucial for hair growth and stem cell renewal, and Mapk signaling helps maintain these processes.
34 citations,
July 2020 in “American journal of human genetics” Changes in the SREBF1 gene cause a rare genetic skin and hair disorder.
33 citations,
June 2020 in “Journal of Clinical Investigation” Stress in hair follicle stem cells causes inflammation in a chronic skin condition through a specific immune response pathway.
33 citations,
July 2018 in “Trends in cell biology” Metabolism plays a key role in determining stem cell fate.
32 citations,
February 2020 in “The Journal of clinical investigation/The journal of clinical investigation” A protein called IL-36γ causes skin side effects from certain cancer treatments when combined with a common skin bacteria.
31 citations,
August 2021 in “Stem Cell Research & Therapy” The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.
29 citations,
January 2021 in “Journal of nanobiotechnology” Tiny particles from brain cells help hair grow by targeting a specific hair growth pathway.
25 citations,
July 2022 in “Developmental cell” Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.
25 citations,
March 2018 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” VDR regulation varies by tissue and is crucial for its biological functions.
25 citations,
December 2007 in “Developmental biology” Clim proteins are essential for maintaining healthy corneas and hair follicles.
24 citations,
May 2018 in “Indian Journal of Dermatology, Venereology and Leprology” 22 citations,
August 2020 in “Cells” TGM3 is important for skin and hair structure and may help diagnose cancer.
22 citations,
January 2011 in “Indian Journal of Dermatology/Indian journal of dermatology” Cow placenta extract may help hair grow by increasing a growth factor but is less effective than minoxidil.
21 citations,
May 2022 in “Frontiers in Cell and Developmental Biology” Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.
21 citations,
January 2022 in “Biomaterials Science” RNA delivery is best for in-body use, while RNP delivery is good for outside-body use. Both methods are expected to greatly impact future treatments.
21 citations,
November 2021 in “Cells” Hedgehog pathway inhibitors can treat certain aggressive cancers but face limitations like resistance and side effects.
19 citations,
June 2022 in “Molecular therapy. Nucleic acids” A specific RNA, circNlgn, contributes to heart damage and scarring caused by the cancer drug doxorubicin.
18 citations,
July 2022 in “Frontiers in Immunology” Volatile organic compounds can cause inflammation and increase the risk of autoimmune diseases.