Characterization and Functional Analysis of the WIF1 Gene and Its Role in Hair Follicle Growth and Development of the Angora Rabbit

September 2022 in “ World Rabbit Science ”

Bohao Zhao, Jiali Li, Xiyu Zhang, Zhiyuan Bao, Yang Chen, Xinsheng Wu

WIF1 gene hair follicle HF growth LEF1 CCND1 β-catenin/TCF transcriptional activity cell apoptosis cellular proliferation

TLDR The WIF1 gene is crucial for hair growth in Angora rabbits.

The study on Angora rabbits reveals that the WIF1 gene, which encodes a 379 amino acid protein, plays a crucial role in hair follicle (HF) growth and development. The gene is unstable, hydrophilic, and extracellular, and is significantly downregulated in high wool-producing rabbits. Functional analyses indicate that WIF1 regulates HF growth-related genes and proteins, such as LEF1 and CCND1, by activating β-catenin/TCF transcriptional activity, promoting cell apoptosis, and inhibiting cellular proliferation. These findings highlight the importance of WIF1 in HF development and provide a theoretical basis for further research in this area.

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