December 2023 in “Kiểm nghiệm và An toàn thực phẩm/Kiểm nghiệm và An toàn thực phẩm (online)” This study developed a liquid chromatography with tandem mass spectrometry method to detect sex hormones in health supplements from Hanoi, Vietnam, finding three out of 16 samples contained sex hormones, including banned testosterone at low levels (~0.5 mg/kg).
114 citations
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May 2001 in “Development” This study found that overexpressing the Hoxc13 gene in mice causes hair loss and a skin condition similar to ichthyosis, identifying several gene targets that may regulate hair growth.
March 2023 in “Journal of Drugs in Dermatology” This paper reviews the role of various hormonal therapies in treating hidradenitis suppurativa and does not report new clinical results.
15 citations
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January 2012 in “International journal of trichology” This study found that the HairCheck® device, demonstrating high correlation between its Hair Mass Index and hair characteristics such as strand number and diameter, may be an effective tool for assessing hair mass changes in alopecia patients.
8 citations
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March 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports that the near-naked hairless mutation in mice is not an allele of the Hairless gene but may involve a mutation in a linked gene or a regulatory mutation.
4 citations
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March 2021 in “Journal of Histotechnology” In this study, researchers observed that hidradenitis suppurativa lesions were associated with reduced collagen and elastin, and increased neovascularization in areas with chronic inflammation.
September 2017 in “Journal of Investigative Dermatology” This study found that hyaluronic acid increased the size and cell proliferation of mixed aggregates in a 3D culture model, indicating its role in human hair follicle germ-like structure formation without enhancing dermal papilla cell markers.
4 citations
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January 2018 in “International Journal of Trichology” This case report describes a 4-year-old girl with hypotrichosis and juvenile macular dystrophy, linked to mutations in the cadherin 3 gene affecting P-cadherin expression.
November 2011 in “Molecular Cancer Therapeutics” This study discusses the involvement of Hedgehog signaling in various human cancers, detailing different mechanisms of pathway activation and highlighting the potential for therapeutic targeting through pathway inhibition.
In this case report, a 36-year-old patient undergoing secukinumab treatment for psoriasis experienced both hepatitis B reactivation and hair discoloration, suggesting a potential link between these effects, though further studies are needed to understand this relationship.
3 citations
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January 2019 in “JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH” This study found that idiopathic hirsutism was the most common cause of hirsutism among patients, and insulin resistance was significant in those with Hyperandrogenic Insulin Resistant Acanthosis Nigricans Syndrome.
In preclinical studies, topical CUR61414 reduced Hh signaling and shrank BCCs in mice, but this study found no clinical efficacy in human superficial or nodular BCCs.
2 citations
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April 2008 in “Experimental Dermatology” This article reviews the pathophysiology of hidradenitis suppurativa and suggests that a complex interplay of genetic, immunological, and biomechanical factors contributes to the condition, but presents no new clinical findings.
This study found that hyaluronic acid increased the size of hair follicle germ-like aggregates and the number of proliferative cells but did not maintain specific markers during the process.
April 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” This source reports that a study by Liu et al. analyzed genetic factors influencing adalimumab response in hidradenitis suppurativa, finding a specific genetic variant (SNP rs59532114) associated with an inadequate response to the treatment due to increased abscess and inflammatory nodule counts.
41 citations
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May 2020 in “Frontiers in immunology” This review discusses the genetic, autoinflammatory, and keratinization factors involved in hidradenitis suppurativa and presents the concept of classifying it as an autoinflammatory keratinization disease, but reports no new clinical results.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study generated a transcriptomic map of human hair follicles, identifying compartment-specific gene expression profiles that can aid in developing targeted therapies for hair follicle disorders.
68 citations
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November 2011 in “The American journal of pathology” This review discusses the role of the hedgehog signaling pathway in hematological cancers and its potential as a therapeutic target; it reports no new clinical findings.
17 citations
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March 2012 in “Journal of biological chemistry/The Journal of biological chemistry” In this study, researchers found that overexpression of the hairless protein in Hr mutant mice disrupts inner root sheath formation by downregulating Dlx3 and associated keratins in hair follicle development.
4 citations
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November 2020 in “Acta Dermato Venereologica” In this study, patients with specific skin and scalp conditions, including eczematous lesions, showed significant improvement after two weeks of oral tofacitinib treatment, as evidenced by changes in the trunk lesions.
December 2023 in “Research Journal of Pharmacy and Technology” In this study, Hibiscus rosa-sinesis flower extract was found to contain 0.33% quercetin according to HPTLC analysis and 0.37% according to HPLC. Heavy metals measured were within acceptable limits, supporting the standardization of the plant material for efficacy and safety testing.
9 citations
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March 2022 in “Terapevticheskii arkhiv” This article reviews human placenta hydrolysates and their complex molecular mechanisms in treating various conditions but does not present new clinical findings.
29 citations
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February 2001 in “Proceedings of the National Academy of Sciences” This study found that the HS III element in the K14 gene's regulatory sequence promotes gene expression in inner root sheath keratinocytes, highlighting cooperative interactions in keratinocyte-specific gene regulation.
8 citations
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March 2022 in “Frontiers in Cell and Developmental Biology” This study found that intravenous transplantation of human hair follicle-derived mesenchymal stem cells improved trabecular bone mass in osteoporotic mice by enhancing bone formation and reducing bone resorption.
11 citations
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May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology” This review explores the evaluation and treatment of hirsutism, emphasizing a systematic approach to uncovering its causes and recommending combination therapies for effective management, but presents no new results.
6 citations
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May 2012 in “Archives of Dermatological Research” This study reports a novel missense mutation in the HR gene in a 68-year-old Hungarian woman with alopecia universalis and limb deformities, suggesting a need for further research on its role in these conditions.
1 citations
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September 2008 In this study, herbal extracts were associated with increased hair regrowth in mice when compared to the negative and vehicle control groups, potentially due to enhanced activity of certain enzymes and growth factors.
220 citations
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May 2017 in “JAMA dermatology” This study found that the skin microbiome in patients with hidradenitis suppurativa differs significantly from healthy controls, suggesting a potential link between microbial imbalance and the disease.
4 citations
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November 2022 in “Acta dermato-venereologica” This study found that patients with hidradenitis suppurativa had lower trabecular bone score and total hip bone mineral density compared to controls, with a high prevalence of vitamin D deficiency.
8 citations
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June 2001 in “Journal of Biological Chemistry” This study found that the truncated hHb1-DeltaN transcript in breast cancer cells is produced by a cryptic intron promoter and responds to DNA demethylation, potentially altering cancer cell adhesion.