Simultaneous HBV Reactivation and Hair Discoloration Under Secukinumab Treatment

A 36-year-old male with psoriasis experienced simultaneous HBV reactivation and hair discoloration while undergoing secukinumab treatment. Despite negative Hbs Ag and normal liver transaminase levels, HBV-DNA PCR became positive in the second year of treatment. The patient, who had not dyed his hair or used additional medications, developed reddish hair discoloration. Secukinumab was continued alongside entecavir, which led to a negative HBV-DNA PCR after three months, though hair discoloration persisted. This case highlights the importance of serial HBV-DNA PCR monitoring in patients with Anti-Hbc IgG positivity and suggests a potential link between viral infections and changes in hair color, warranting further research.