The Near-Naked Hairless Mutation Disrupts Hair Formation but Is Not Due to a Mutation in the Hairless Coding Region

March 2007 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Yutao Liu, Suchita Das, Robert E. Olszewski, Donald A. Carpenter, Cymbeline T. Culiat, John P. Sundberg, Patricia Soteropoulos, Xiao‐Chen Liu, Mitchel J. Doktycz, Edward J. Michaud, Brynn H. Voy

hairless mutation HrN dystrophic hairs follicular dystrophy DNA microarray analysis gene expression hair structure Hr gene regulatory mutation

TLDR The near-naked hairless mutation causes hair loss but is not due to a mutation in the hairless gene itself.

The study investigated the near-naked hairless (HrN) mutation in mice, which caused hair loss as the postnatal coat emerged and displayed semi-dominant inheritance. HrN/HrN mice had dystrophic hairs that failed to emerge from follicles, while HrN/+ mice had a sparse coat and milder follicular dystrophy. DNA microarray analysis showed downregulation of many genes crucial for hair structure in HrN/HrN mice, with increased Hr expression. Sequencing the Hr gene regions did not identify the mutation, suggesting HrN might result from a mutation in a closely linked gene or a regulatory mutation in Hr.

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The Near-Naked Hairless Mutation Disrupts Hair Formation but Is Not Due to a Mutation in the Hairless Coding Region

Research cited in this study

research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

research Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling

research Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA

research Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling

research HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression

research The Hairless Gene Mutated in Congenital Hair Loss Disorders Encodes a Novel Nuclear Receptor Corepressor

research Overexpression of Hoxc13 in Differentiating Keratinocytes Results in Downregulation of a Novel Hair Keratin Gene Cluster and Alopecia

research A Distinct Gene Close to the Hairless Locus on Chromosome 8p Underlies Hereditary Marie Unna Type Hypotrichosis in a German Family

research Mu-Crystallin, Thyroid Hormone-Binding Protein, Is Expressed Abundantly in the Murine Inner Root Sheath Cells

research Lanceolate Hair-J (LahJ): A Mouse Model for Human Hair Disorders

research Forkhead/Winged-Helix Transcription Factor Whn Regulates Hair Keratin Gene Expression: Molecular Analysis of the Nude Skin Phenotype

research Whn and mHa3 Are Components of the Genetic Hierarchy Controlling Hair Follicle Differentiation

research Molecular and Functional Aspects of the Hairless (Hr) Gene in Laboratory Rodents and Humans

research Towards Defining the Pathogenesis of the Hairless Phenotype

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