The Near-Naked Hairless Mutation Disrupts Hair Formation but Is Not Due to a Mutation in the Hairless Coding Region

March 2007 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Yutao Liu, Suchita Das, Robert E. Olszewski, Donald A. Carpenter, Cymbeline T. Culiat, John P. Sundberg, Patricia Soteropoulos, Xiao‐Chen Liu, Mitchel J. Doktycz, Edward J. Michaud, Brynn H. Voy

hairless mutation HrN dystrophic hairs follicular dystrophy DNA microarray analysis gene expression hair structure Hr gene regulatory mutation

TLDR The near-naked hairless mutation causes hair loss but is not due to a mutation in the hairless gene itself.

The study investigated the near-naked hairless (HrN) mutation in mice, which caused hair loss as the postnatal coat emerged and displayed semi-dominant inheritance. HrN/HrN mice had dystrophic hairs that failed to emerge from follicles, while HrN/+ mice had a sparse coat and milder follicular dystrophy. DNA microarray analysis showed downregulation of many genes crucial for hair structure in HrN/HrN mice, with increased Hr expression. Sequencing the Hr gene regions did not identify the mutation, suggesting HrN might result from a mutation in a closely linked gene or a regulatory mutation in Hr.

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