Bone Metabolism in Patients With Hidradenitis Suppurativa: A Case-Control Study

This case-control study with 81 patients with hidradenitis suppurativa (HS) and 79 controls found that HS is associated with lower levels of serum 25-hydroxyvitamin D (25OHD), with 62% of HS patients having vitamin D deficiency. Additionally, patients with HS had increased serum amino-terminal pro-peptide of type 1 collagen (PINP) levels, decreased C-terminal telopeptide of type 1 collagen (CTX) levels, and lower trabecular bone score values compared to controls. While lumbar bone mineral density was similar between the two groups, total hip bone mineral density was lower in HS patients. The study concluded that HS patients have disturbances in bone metabolism, as evidenced by lower trabecular bone score and total hip bone mineral density, and a high prevalence of vitamin D deficiency.