Clinical and Investigative Study of Hirsutism
January 2019
in “
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
”
hirsutism idiopathic hirsutism PCOS HAIR-AN syndrome hypothyroidism late-onset CAH acne female pattern hair loss acanthosis nigricans serum LH LH:FSH ratio serum 17-OH progesterone insulin resistance HOMA-IR polycystic ovary syndrome congenital adrenal hyperplasia luteinizing hormone follicle-stimulating hormone 17-hydroxyprogesterone
TLDR Idiopathic hirsutism is the most common cause, followed by PCOS, and insulin resistance should be checked in patients with acanthosis nigricans.
This study investigated the causes and characteristics of hirsutism in 50 female patients, finding that idiopathic hirsutism was the most common cause (40%), followed by PCOS (32%), HAIR-AN syndrome (16%), hypothyroidism (8%), and late-onset CAH (4%). Associated symptoms included acne (40%), female pattern hair loss (26%), and acanthosis nigricans (20%). Significant findings included elevated serum LH and LH:FSH ratio in PCOS and CAH, and increased serum 17-OH progesterone in CAH. The HAIR-AN group showed significant differences in waist circumference, serum fasting insulin, and HOMA-IR, highlighting the need to assess insulin resistance in hirsutism patients with acanthosis nigricans for appropriate management.
