Viewpoint 1

Hidradenitis suppurativa (HS) was a challenging skin condition characterized by recurrent inflammatory lesions, primarily affecting inverse areas of the body. It was not infectious, despite appearances, and involved hair follicle disease with significant scarring. The etiology was complex, potentially involving genetic factors, bacteria, immune responses, and environmental triggers like tobacco or trauma, but no single cause was identified. Treatments, including antimicrobials and anti-inflammatories, were often ineffective, and the disease significantly impacted patients' quality of life. The pathophysiology involved hair follicle rupture, inflammation, and scarring, with biomechanical and immune factors possibly playing roles. Understanding HS could also provide insights into broader wound healing and fistula formation issues.