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Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The exact cause of increased 5α-reductase activity leading to hirsutism in women is still unknown.

Benign Prostatic Hyperplasia may be caused by changes in how the body processes male hormones.

Blood tests are needed to confirm high male hormone levels in women with PCOS, as physical signs alone are not reliable.

The document suggests a need for collaboration, better evidence, and a responsible framework to safely and effectively advance regenerative therapies to clinical use.

Acne is a common skin condition linked to diet, hormones, and genetics, and early treatment can prevent scarring.

Anti-androgens can help reduce the effects of male hormones on the skin.

Hair follicle biology advancements may lead to better hair growth disorder treatments.

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Hair follicles create different cell layers and proteins, controlled by various molecules.

TGFα gene mutation in mice causes abnormal skin, wavy hair, curly whiskers, and sometimes eye inflammation.

Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.

Hair growth is cyclic and influenced mainly by local factors.

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

Hair cortisol levels can show increased stress during late pregnancy but only for up to six months.

Fat-related cells are important for initiating hair growth.

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

Hair color is determined by melanin produced and transferred in hair follicles.

Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.

Most adult chronic hair pullers are women who started in their early teens, often have other mental health issues, and may pull hair due to underlying psychiatric conditions.

Activating TERT in mice skin boosts hair growth by waking up hair follicle stem cells.

Hair follicle size and distribution vary significantly across different body sites.

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.