45 citations
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November 2017 in “Biomaterials” This study demonstrated a method for large-scale preparation of self-sorted hair follicle germs in vitro, which successfully generated hair follicles when transplanted into the skin of nude mice.
January 2022 in “Institutional Repositories DataBase (IRDB)” This study found that pen-type microwells enhanced hair follicle germ formation by promoting cell assembly, suggesting microwell array geometry significantly influences in vitro hair follicle development.
27 citations
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October 1998 in “Differentiation” Basonuclin helps identify and track hair follicle development and cycling in mice.
January 1998 in “Differentiation” Basonuclin is crucial for hair follicle development and cycling in mice.
19 citations
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July 2011 in “Microscopy and Microanalysis” This article reviews the role of adult stem cells in tissue homeostasis and wound repair, focusing on their regulation within the murine hair follicle's specialized niche, but it presents no new findings.
23 citations
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September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” In this mouse study, NF-κB was shown to play a role in hair follicle cycling and morphogenesis, with specific activity patterns differing by hair type and involving noncanonical signaling for zigzag hair bending.
15 citations
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September 1999 in “British Journal of Dermatology” This study found that epimorphin is closely linked to developing hair follicles in human fetuses, suggesting it plays a significant role in hair follicle morphogenesis.
August 2025 in “Biomaterials” In this study, researchers developed a novel therapy using the secretome of human fetal cartilage progenitor cells, which successfully regenerated functional hair follicles in animal models and significantly increased hair regrowth, suggesting potential as a new treatment for androgenic alopecia.
60 citations
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November 2013 in “Development” This study found that the creation of hair follicle lumens in mice is driven by the outward migration of keratin 79-positive cells, suggesting a novel mechanism for generating hollow cores in hair follicles.
November 2020 in “Research Square (Research Square)” In a mouse model, this study found that intradermal keratin injection stimulated hair growth and suggested its potential use for treating hair loss by promoting hair regeneration.
3 citations
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December 2013 in “Journal of Cell Science” This study found that K79+ keratinocytes migrate outward to help form the hair follicle lumen both during development and adult regeneration, revealing a novel mechanism of hair follicle formation in mice.
42 citations
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January 2017 in “Stem cells international” This study found that while extracellular matrix components like hyaluronic acid promoted larger organoid formation, other matrix components hindered hair follicle germ assembly in an in vitro model.
11 citations
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March 2021 in “Journal of Bioscience and Bioengineering” This study demonstrated that adding human adipose-derived stem cells to hair follicle germ-like aggregates significantly improved hair shaft generation in transplanted nude mice, suggesting a promising strategy for hair regenerative medicine.
22 citations
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December 2013 in “Molecular biology of the cell” This study found that ILK deficiency disrupts hair follicle development by impairing cell polarity and laminin-511 assembly, but these defects can be partially reversed with exogenous laminin-511.
10 citations
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August 2020 in “Journal of Bioscience and Bioengineering” This study reports that using activated platelet-rich plasma releasate in the preparation of bioengineered hair follicle germs enhanced follicular gene expression and significantly improved hair regeneration in vitro.
June 2022 in “Scientific Reports” This study found that prevelex coatings on microwell array devices enhanced the formation of uniform cell spheroids and enabled the development of hair follicles in tissue engineering applications.
18 citations
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October 2021 in “Frontiers in Physiology” This review summarizes recent research on the molecular properties and functions of L-PGDS and PGD2, but reports no new findings, highlighting their pathophysiological roles and guiding future studies.
1 citations
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January 2017 The document outlines criteria to identify and differentiate neoplasms based on follicular characteristics.
September 2017 in “Journal of Investigative Dermatology” This study found that hyaluronic acid increased the size and cell proliferation of mixed aggregates in a 3D culture model, indicating its role in human hair follicle germ-like structure formation without enhancing dermal papilla cell markers.
This study found that human hair follicles can be used to generate induced pluripotent stem cells, which can then efficiently differentiate back into keratinocytes.
31 citations
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September 2012 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that proper levels of retinoic acid, controlled by the enzyme Cyp26b1, are essential for normal hair follicle development and morphogenesis in mice.
6 citations
,
January 2019 in “Biochemical and Biophysical Research Communications” This study suggests that Sox13, although dispensable for epidermal development, serves as a marker for early hair follicle development in Sox13-LacZ knock-in mice.
April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” In a keratinocyte-specific knockout mouse model, this study found that deleting GRK2 disrupted hair follicle homeostasis, causing cyst-like structures, abnormal growth patterns, and eventual hair loss, suggesting potential links to immune-mediated alopecias.
51 citations
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May 2019 in “Biomaterials” This study developed a method for generating germ-like tissues called bbHFGs, which efficiently promoted hair follicle formation in mice, potentially advancing hair regenerative medicine applications.
70 citations
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April 2020 in “Journal of Molecular Cell Biology” This review summarizes recent advances in organoid technology for generating tissue models from the three germ layers and reports no new experimental results.
November 2013 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Keratin 79 cells help form and regenerate hair canals.
February 2023 in “International journal of molecular sciences” This study used infrared spectral imaging to show for the first time the distribution of glypican-4 and glypican-6 in hair follicles across different growth phases, highlighting the potential of this technique for studying alopecia.
2 citations
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January 2020 in “Methods in molecular biology” This study describes a protocol for generating hair follicle germ-like organoids from human skin cells, which may aid in alopecia drug discovery and understanding hair follicle regeneration.
January 2026 in “PLoS Biology” This study used developing mouse hair follicles to explore early epithelial bud formation, finding that the Rho GTPase regulator ARHGEF3 plays a crucial role in regulating cell fate and cadherin patterning, with knockouts showing disrupted morphology and increased straight hair follicle growth.
176 citations
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January 2013 in “Proceedings of the National Academy of Sciences” This study reveals an antagonistic competition between BMP and Wnt signaling within stem cells, influencing their fate towards hair germ characteristics based on the BMP/Wnt activity ratio.