Organoid Technology for Tissue Engineering

April 2020 in “ Journal of Molecular Cell Biology ”

Juan He, Xiaoyu Zhang, Xinyi Xia, Ming Han, Fei Li, Chunfeng Li, Yunguang Li, Dong Gao

TLDR Organoid technology helps create mini-organs for studying diseases and testing drugs.

Organoid technology, which emerged as a systematic field in the decade prior to 2020, played a significant role in tissue engineering by enabling the formation of 3D structures from stem cells that closely resembled in vivo organs. These organoids, derived from versatile organs, served as powerful models for understanding developmental mechanisms, modeling diseases, and screening drug candidates. The review summarized advancements in generating organoids from tissues of the three germ layers and discussed the technology's limitations and future potential in tissue engineering.

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