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    Glossary hair cell differentiation

    process where cells become specialized to form hair structures

    Hair cell differentiation is the process by which unspecialized cells develop into specialized hair cells, which are responsible for producing hair. This involves a series of genetic and biochemical changes that enable these cells to form the structures necessary for hair growth, such as the hair shaft and follicle. Understanding this process is crucial for developing treatments for hair loss conditions like alopecia.

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    1. A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea eLife · 2019 · 15 citations
    2. In vitro Differentiation of Adipose-Derived Stem Cells into Hair Cell-Like Cells in Guinea Pigs Journal of Otology · 2007 · 3 citations
    3. A Low Dose of Rapamycin Promotes Hair Cell Differentiation by Enriching SOX2+ Progenitors in the Neonatal Mouse Inner Ear Organoids. PubMed · 2024
    4. Faculty Opinions recommendation of A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2019
    5. Author response: A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea 2019
    6. Decision letter: A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea 2019
    7. ES Cell Differentiation Into the Hair Follicle Lineage In Vitro Humana Press eBooks · 2003 · 13 citations
    8. Intrinsic activation of cell growth and differentiation in ex vivo cultured human hair follicles by a transient endogenous production of ROS Scientific reports · 2019 · 9 citations
    9. Hair follicle differentiation‐specific keratin expression in human basal cell carcinoma Clinical and Experimental Dermatology · 2019 · 45 citations
    10. Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22 PLOS Genetics · 2015 · 52 citations
    11. Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix European Journal of Cell Biology · 2017 · 30 citations
    12. MicroRNA-149-Mediated MAPK1/ERK2 Suppression Attenuates Hair Follicle Stem Cell Differentiation Human Gene Therapy · 2022 · 2 citations
    13. Thymosin Beta 4 Induces Hair Growth via Stem Cell Migration and Differentiation Annals of the New York Academy of Sciences · 2007 · 53 citations
    14. Human basal cell carcinoma: the induction of anagen hair follicle differentiation Clinical and experimental dermatology · 2019 · 3 citations
    15. In vitro Differentiation of Hair Follicle Stem Cell into Keratinocyte by Simvastatin Iranian Biomedical Journal · 2019 · 10 citations
    16. Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia British Journal of Dermatology · 2012 · 95 citations
    17. Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia Molecular and Cellular Endocrinology · 2016 · 47 citations
    18. Transcription Factor DLX5 Promotes Hair Follicle Stem Cell Differentiation by Regulating the c-MYC/microRNA-29c-3p/NSD1 Axis Frontiers in Cell and Developmental Biology · 2021 · 4 citations
    19. In vitro neural differentiation of CD34 + stem cell populations in hair follicles by three different neural induction protocols In vitro cellular & developmental biology. Animal · 2014 · 18 citations
    20. [An immunohistochemical study on cell differentiation in the outer root sheath of the normal human anagen hair follicles with antikeratin monoclonal antibodies]. PubMed · 1990 · 6 citations
    21. Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro European Journal of Cell Biology · 2010 · 42 citations
    22. Human hair follicle stem cell differentiation into contractile smooth muscle cells is induced by transforming growth factor-β1 and platelet-derived growth factor BB Molecular Medicine Reports · 2013 · 19 citations
    23. Smurf2-induced degradation of SMAD2 causes inhibition of hair follicle stem cell differentiation Cell Death Discovery · 2022 · 1 citations
    24. Cell Differentiation in Human Anagen Hair and Hair Follicles Studied with Anti-Hair Keratin Monoclonal Antibodies Journal of Investigative Dermatology · 1986 · 81 citations
    25. Corrigendum to “Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro” [Eur. J. Cell Biol. (2010) 769–777] European Journal of Cell Biology · 2012 · 1 citations
    26. Complex Changes in the Apoptotic and Cell Differentiation Programs during Initiation of the Hair Follicle Response to Chemotherapy Journal of Investigative Dermatology · 2014 · 12 citations
    27. miR‑339‑5p negatively regulates loureirin A‑induced hair follicle stem cell differentiation by targeting DLX5 Molecular Medicine Reports · 2018 · 19 citations
    28. FGF22 Secreted by Hair Papilla Cells Regulates Hair Follicle Stem Cell Proliferation and Differentiation Biomolecules · 2025
    29. Nestin as a marker of unipotent epithelial progenitor cell differentiation into outer root sheath keratinocytes in embryonic and adult hair follicles Research Square (Research Square) · 2022
    30. 570 DNA dioxygenases Tet1/2/3 control cell differentiation in the hair follicle keratinocytes via modulating the activity of BMP signaling pathway 2019