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Disrupting Stat3 in hair follicle stem cells greatly reduces skin tumor formation.

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

Hair follicle regeneration may slow tumor growth.

Older skin has higher cancer risk due to inflammation and stem cell issues.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

Lacking cyclin D3 reduces skin cancer growth without affecting normal skin cell growth.

UV exposure reduces Lgr6+ stem cells in mouse skin and they don't significantly contribute to skin cancer development.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Actinic keratosis can lead to skin cancer, is more common in fair-skinned people, and can be reduced with sunscreen and treated effectively.

Understanding where cancer cells come from helps create better prevention and treatment methods.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

Skin cells show flexibility in healing wounds and forming tumors, with potential for treating hair disorders and chronic ulcers.

The document concludes that identifying the specific cells where skin cancers begin is important for creating better prevention, detection, and treatment methods.

Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.

The risk of skin tumors becoming malignant depends on the specific skin cell type affected.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.

Activating c-Myc in skin causes rapid cell growth and changes, but these effects are reversible.

Inactive hair follicle stem cells help prevent skin cancer.

The Wnt signaling pathway is not a major factor in the development of keratoacanthoma, a type of skin tumor.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Older adults have a high rate of skin cancers like basal cell carcinoma and melanoma, mainly due to UV exposure and age.

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

Acanthosis nigricans is a skin condition that may indicate a higher risk for insulin resistance and type 2 diabetes, and more research is needed to understand and treat it.

New melanoma treatments can cause skin side effects, including skin cancer and rashes, but combining treatments may reduce these risks.

Budesonide and N-acetylcysteine reduced tumors and alopecia in mice, regardless of FHIT gene status.

The PP2A-B55α protein is essential for brain and skin development in embryos.