96 citations
,
April 2007 in “Journal of Investigative Dermatology” In this study, co-grafting human keratinocytes with murine dermal papilla-enriched cells produced hair follicle-like structures, but without regular hair formation, suggesting anomalous folliculogenesis.
51 citations
,
August 2013 in “Journal of Investigative Dermatology” This study demonstrated that cultured human dermal papilla cells can induce full hair follicle formation when combined with neonatal foreskin keratinocytes in a grafted dermal-epidermal construct on mice.
68 citations
,
August 2014 in “Stem Cells Translational Medicine” This study found that composite skin constructs containing dermal papilla cells promoted better skin healing and hair regeneration in nude mice, highlighting their role in tissue-engineered skin for severe injuries.
23 citations
,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” This review discusses rodent models of alopecia areata and suggests they are crucial for understanding the autoimmune mechanisms and potential treatments but reports no new clinical results.
19 citations
,
November 2001 in “Journal of Investigative Dermatology Symposium Proceedings” This study observed that human hair follicles with a completely destroyed bulb can regenerate after being grafted onto immunodeficient mice, entering a shortened dystrophic telogen followed by anagen phase.
14 citations
,
January 2021 in “Stem cell research & therapy” This study suggests that interfollicular epidermal keratinocytes with stem-like features may serve as an alternative to follicular keratinocytes for hair regeneration by supporting hair follicle morphogenesis in vivo.
February 2008 in “Medical & surgical dermatology” Some treatments like topical oxygen and stem cells show promise for wound healing and hair growth, but evidence for modern dressings over traditional ones is limited.
April 2019 in “Journal of Investigative Dermatology” This study demonstrated that gene-corrected 3D skin constructs from RDEB patient-derived iPSCs, grafted onto immunocompetent mice, showed normal collagen VII expression after two months.
6 citations
,
February 2014 in “Experimental Dermatology” This review discusses the potential for cellular hair regeneration by building on foundational rodent studies and emphasizes the need for protocols to enhance the inductive properties of human dermal papilla cells.
49 citations
,
September 2007 in “Journal of Investigative Dermatology” The study found that bioengineered hair follicles work when using cells from the same species but have issues when combining human and mouse cells.
9 citations
,
August 2013 in “Journal of Tissue Engineering and Regenerative Medicine” In this study, neonatal murine skin-derived cells transplanted using a mini-chamber method successfully produced robust and normal hair, contrasting with human scalp follicles which did not achieve follicle reconstruction.
8 citations
,
November 2020 in “Nature Communications” This study demonstrates that Tp63-expressing epithelial stem cells from non-skin tissues can respond to skin morphogenetic signals and contribute to the formation of hair follicles, sebaceous glands, and epidermis.
36 citations
,
March 2011 in “Nature Communications” This study found that TSC2-null fibroblast cells from TSC skin hamartomas can induce hair follicle formation and hamartomatous changes in keratinocytes, with active mTOR signaling observable in a mouse xenograft model.
5 citations
,
January 2016 in “Journal of Molecular Histology” Both main and alternative Wnt signaling are important for regrowing rodent whisker follicles.
15 citations
,
April 2014 in “Experimental Dermatology” This study observed that earlier-passage keratinocyte cultures led to superior hair follicle neogenesis in dermal-epidermal composites grafted onto immunodeficient mice, suggesting their potential utility in studying human hair follicle development.
82 citations
,
March 2016 in “Autoimmunity reviews” This review explores animal models of alopecia areata, particularly focusing on the insights they've provided into the disease's immune mechanisms and potential treatment approaches, without reporting new experimental data.
1 citations
,
January 2024 in “Cellular & Molecular Biology Letters” This review evaluated the potential of adipose-derived stem cells (ADSCs) for burn treatment, finding promising regenerative healing effects, though most findings are at early experimental stages primarily in animal models.
4 citations
,
July 2014 in “Journal of Investigative Dermatology” This study suggests that age-related regenerative decline in hair follicles may be due to an imbalance of signals affecting stem cell activation, with follistatin potentially promoting renewal.
18 citations
,
August 2015 in “International Journal of Molecular Sciences” This study developed an efficient method for isolating and enriching multipotent ovine hair follicle stem cells, which may aid in research on the ovine hair cycle and future wool production.
30 citations
,
October 2012 in “Current Opinion in Endocrinology, Diabetes and Obesity” This review discusses the effects of thyroid hormone on the skin and explores the potential for using it to treat skin diseases, but reports no new clinical results.
59 citations
,
September 2008 in “Experimental dermatology” This study reports that C3H/HeJ mice and DEBR rats serve as effective models for screening potential treatments for human alopecia areata, despite certain challenges in predictability and cost.
Growing hair follicles from cultured cells could potentially treat baldness, but more research is needed.
1 citations
,
November 2005 in “Journal of Andrology” This meeting abstract details various lectures and workshops from the 30th Annual Meeting of the American Society of Andrology, including findings on genetic and physiological factors affecting male fertility, but reports no new clinical results.
November 2025 in “Bioengineering” In this study, researchers used a 3D printing technique to spatially pattern human dermal papilla cell spheroids in a collagen matrix, enhancing skin and hair regeneration in a mouse model, with notable upregulation of key genes for hair follicle formation compared to traditional cell cultures.
85 citations
,
December 2017 in “Developmental Biology” This review discusses mammalian models of epimorphic regeneration to define a vertebrate regeneration blastema, concluding that regenerative failure likely stems from cellular responses to the microenvironment after injury, not progenitor cell availability, and calls for targeted modification studies in mammals to advance human regeneration.
29 citations
,
March 2015 in “Journal of Investigative Dermatology” This study provides evidence that Cyclosporine A inhibits catagen development in human hair follicles, suggesting different underlying mechanisms from those observed in rodent studies.
28 citations
,
January 2013 in “Journal of Thyroid Research” This review discusses the potential therapeutic use of thyroid hormones on skin conditions, highlighting the need for further research but reporting no new experimental results.
15 citations
,
September 2007 in “Cell & tissue research/Cell and tissue research” This study suggests that human embryonic stem cells may improve skin graft quality and functionality by enabling the identification and amplification of early ectodermal progenitors, pending confirmation from preclinical studies.
48 citations
,
December 2004 in “Differentiation” This study found that cultured dental papilla cells from various mammals can induce hair follicle regeneration and influence tissue formation, with outcomes dependent on donor age, tooth type, and host environment.
63 citations
,
September 2009 in “Regenerative Medicine” This study developed a method for expanding human dermal papilla cells in vitro while maintaining their ability to induce hair growth, advancing the potential for follicular cell implantation as a treatment for hair loss.