4 citations
,
February 2024 in “The Journal of Urology” This study reports that adding androgen deprivation therapy to salvage radiation therapy for patients with non-metastatic biochemical recurrence of prostate cancer after radical prostatectomy improves progression-free survival, particularly in those with higher post-prostatectomy PSA levels.
3 citations
,
May 2002 in “PubMed” This article reviews the causes and treatments of hypertrichosis and hirsutism and reports no new clinical findings; the authors compare diagnostic strategies and discuss available treatment options.
This paper addresses diagnostic criteria and treatment options for polycystic ovary syndrome, emphasizing lifestyle changes and combination oral contraceptives as primary management strategies, but it reports no new clinical results.
23 citations
,
June 1997 in “Baillière's clinical obstetrics and gynaecology” This article discusses various diagnostic categories and treatments for hyperandrogenism, with a focus on polycystic ovary syndrome and reports no new clinical findings, calling for specific treatments and lifestyle changes.
19 citations
,
March 2022 in “International Journal of Environmental Research and Public Health” This review covers the neuroendocrine aspects of polycystic ovary syndrome, focusing on hormones and neurotransmitters like GnRH and kisspeptin, but does not report new clinical findings.
19 citations
,
March 1994 in “Fertility and sterility” This study found that treatment with a GnRH agonist and estrogen and progestin replacement significantly improved hirsutism scores and hair growth rates in women with polycystic ovarian disease.
8 citations
,
February 2021 in “Journal of the American Heart Association” This study observed that medical castration for prostate cancer prolongs the QT/QTc intervals, potentially leading to serious arrhythmias like torsade de pointes and ventricular fibrillation, even in patients without prior QT prolongation risk.
2 citations
,
February 2023 in “F&S Reports” This study found that elagolix treatment did not normalize the ovulatory cycle in patients with polycystic ovarian syndrome.
1 citations
,
August 2022 in “Veterinary medicine and science” This review discusses various diagnostic and treatment strategies for canine prostate diseases, including pharmacological options and advanced procedures, but reports no new clinical results.
January 2025 in “Brazilian Journal of Veterinary Medicine/Revista Brasileira de Medicina Veterinária” This source describes the first successful use of a deslorelin acetate implant to treat alopecia X in a neutered female dog, achieving profuse hair regrowth in 9 months, suggesting an uncomplicated and cost-effective alternative after melatonin failure.
June 2020 in “AACE clinical case reports” This case report illustrates that Leydig cell tumors, despite causing significantly elevated androgen levels, can be difficult to localize due to their small size, as demonstrated in a 42-year-old woman whose tumor was only identified after oophorectomy.
29 citations
,
July 2011 in “Pediatrics in review” This article reviews various aspects of puberty, particularly focusing on the staging of sexual maturity and the factors influencing pubertal onset, but reports no new empirical results.
November 2022 in “The Journal of Clinical Endocrinology and Metabolism” This review discusses the causes and recommended clinical investigations for postmenopausal hyperandrogenism, highlighting the role of androgen excess in symptoms like hirsutism and its association with metabolic disorders.
5 citations
,
January 2017 in “Acta Endocrinologica” This case report discusses a postmenopausal woman whose hyperandrogenism and metabolic symptoms improved significantly after the surgical removal of an ovarian Leydig cell tumor, confirmed post-operatively.
175 citations
,
January 2020 in “European Journal of Endocrinology” These guidelines recommend testing thyroid function in patients with obesity due to common hypothyroidism, and highlight that weight loss is crucial for addressing hormonal imbalances, with only modest weight loss benefits from treating endocrine disorders.
36 citations
,
June 2014 in “PLOS ONE” This study found that men with persistent sexual side effects after using finasteride for androgenetic alopecia had higher androgen receptor expression in certain tissues compared to those who never used the drug.
19 citations
,
December 2021 in “Endocrine Reviews” This review highlights therapeutic options for inducing puberty in males and females with delayed puberty, emphasizing the need for larger trials to establish the best approaches.
19 citations
,
May 2020 in “American journal of men's health” This review discusses androgen therapy in adolescents, detailing current practices and noting the limited use of commercially available testosterone or dihydrotestosterone formulations; no new results are reported.
17 citations
,
February 2004 in “PubMed” This review discusses symptom-driven treatment approaches for PCOS, focusing on ovulation induction, androgen reduction, and weight management, and reports recent advances like recombinant FSH and GnRH-agonist protocols without providing new clinical results.
15 citations
,
May 2010 in “Pediatrics in Review” This article reviews the normal and delayed maturation of the HPG axis and pubertal development in boys and girls, emphasizing clinical aspects of diagnosing and managing delayed puberty, but it reports no new clinical findings.
9 citations
,
March 2022 in “Frontiers in Endocrinology” This study found that PCOS is common among Iranian women, with phenotypes involving hyperandrogenism exhibiting worse lipid profiles and higher rates of metabolic syndrome compared to healthy women.
6 citations
,
August 2023 in “European journal of endocrinology” This review discusses the 2023 International Guideline for PCOS assessment and management, highlighting updated evidence-based recommendations and practice points aimed at improving care and health outcomes, but notes that research quality remains generally low to moderate.
6 citations
,
December 2022 in “Frontiers in Pharmacology” This review examines the potential therapeutic effects and mechanisms of quercetin for treating polycystic ovary syndrome, noting improved clinical parameters in some studies but presenting no new results.
3 citations
,
January 2024 in “Revista da Associação Médica Brasileira” In this study, the authors reported that depression and anxiety are more prevalent in patients with polycystic ovary syndrome compared to healthy women, reinforcing the need for routine mental health screening in this population.
2 citations
,
July 2023 in “AACE Clinical Case Reports” In this case study, researchers identified a Leydig cell tumor in a 56-year-old postmenopausal woman with virilization symptoms by using ovarian vein sampling, as imaging was nonrevealing, and confirmed the tumor's location using testosterone ratios, which supported previous findings.
1 citations
,
June 2023 in “Reproduction” This review discusses the role of microglia in mediating prenatal androgen effects on the female brain, potentially contributing to PCOS development and neuroendocrine dysfunctions, but reports no new results.
1 citations
,
October 2022 in “Adolescent Health, Medicine and Therapeutics” This article discusses the dermatologic impacts of gender-affirming medical care in transgender adolescents and emphasizes the importance of patient-centered care to improve dermatologic and overall outcomes; it reports no new clinical results.
1 citations
,
January 2022 in “IntechOpen eBooks” This study suggests that while PCOS phenotype does not affect oocyte quality, a combination of hyperandrogenism and chronic anovulation negatively impacts cumulative pregnancy rates in assisted reproduction.
April 2025 in “Middle East Fertility Society Journal” This study established reference values for nine fertility hormones important in diagnosing and monitoring PCOS in Pakistani and other subcontinent populations.
July 2023 in “Journal of Clinical Medicine” In this study, researchers investigated factors predicting resistance to clomiphene citrate in women with anovulatory PCOS, identifying AMH and SHBG levels as significant indicators, but they found no reliable thresholds for predicting resistance to the standard 50 mg/day dose.