The Use of Ovarian Vein Sampling to Lateralize a Virilizing Leydig Cell Ovarian Tumor
July 2023
in “
AACE Clinical Case Reports
”
Studysummary In this case study, researchers identified a Leydig cell tumor in a 56-year-old postmenopausal woman with virilization symptoms by using ovarian vein sampling, as imaging was nonrevealing, and confirmed the tumor's location using testosterone ratios, which supported previous findings.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This case report highlights the effectiveness of ovarian vein sampling (OVS) and adrenal vein sampling (AVS) in diagnosing a virilizing Leydig cell ovarian tumor in a 56-year-old postmenopausal woman, where imaging was inconclusive. The patient's elevated testosterone levels and a left-to-right ovarian testosterone ratio of 41.94 indicated a left-sided tumor, which was confirmed as a 1.0 cm Leydig cell tumor in the left ovary after a bilateral salpingo-oophorectomy. Post-surgery, her testosterone levels normalized, and her symptoms improved. The study supports using a left-to-right ovarian vein testosterone ratio of ≥15 for tumor lateralization and suggests that more cases could help establish guidelines for interpreting OVS results.
