The Treatment of Polycystic Ovary Syndrome

    February 2004 in “ PubMed ”
    S. Ajossa, S. Guerriero, Am Paoletti, Martino Orrù, G. B. Melis
    TLDR PCOS treatment focuses on inducing ovulation, reducing androgens, and managing long-term health risks with medications and lifestyle changes.
    The treatment of polycystic ovary syndrome (PCOS) in 2004 focused on symptom-oriented approaches due to the unclear etiology of the condition. The primary goals were to induce ovulation for conception, reduce androgen levels, manage body weight, and mitigate long-term health risks like diabetes and cardiovascular disease. Clomiphene citrate (CC) was the first-line treatment for ovulation induction, with alternatives for CC-resistant patients including gonadotrophin therapy and laparoscopic ovarian diathermy. Recombinant FSH (rFSH) showed promise for being more effective than urinary FSH. The addition of GnRH-agonist could enhance treatment outcomes. Metformin and cabergoline were also under investigation. For hirsutism, treatments aimed at androgen suppression included oral contraceptives, GnRH analogues, and insulin-sensitizing agents. Weight reduction and exercise were recommended to improve menstrual disturbances, infertility, and insulin resistance.
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