Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study observed that inducible deletion of the Ugcg gene in mouse epidermis led to a significant reduction in GlcCers and epidermal POS-Cers, causing impaired skin barrier function and delayed wound healing.

This study analyzed the lipid composition of mouse hair, focusing on sphingolipids, and found significant differences in ceramides, glucosylceramides, and sphingomyelins between hair follicles and hair shafts.

This study found that in mice, deleting the keratin 10 gene enhances sebocyte differentiation and increases secretion of sebum and certain lipids without affecting proliferation-associated keratins.

In this study, a high-fat, high-cholesterol diet in atherosclerotic mice led to skin inflammation and hair problems, which could be reversed by inhibiting glycosphingolipid synthesis.

This study found that inactivating CerS4 in mouse epidermis disrupts lipid homeostasis and is crucial for maintaining, but not forming, the skin barrier.

Ceramide Synthase 4 is crucial for healthy skin barrier function.

This study reports a novel LC/MS method that separates and analyzes all known ceramide subclasses in human stratum corneum, identifying a new subclass, CER [EOdS], with minimal sample preparation.

This study suggests that decreased levels of dihydroceramide in hair may serve as a biomarker for the progression of alopecia.

This study found that mice deficient in ceramide synthase 4 showed altered sebum composition and progressive hair loss due to obstructed hair canals.

This study observed that rat dermal tissue cultures, rich in hair follicle cells, produce various glycosaminoglycans, including hyaluronic acid and dermatan sulfate, which change in synthesis and sulfation patterns over time.

This study explored the carbohydrate composition of plasma cell membranes in human embryonic epidermis over various gestational ages and found specific patterns that may inform future diagnostic and therapeutic approaches for dermatoses.

This study found that formulations containing saccharide isomerate significantly improved scalp flaking, sebum secretion, and transepidermal water loss compared to placebo in an adult Chinese population with dandruff.

This study revealed that deficiency in the enzyme FA2H in mice affected sebaceous gland function, altered sebum composition, and caused cycling alopecia, highlighting FA2H's role in hair follicle homeostasis.

This paper highlights the growing scientific interest in plant extracts for cosmetics due to their potential benefits, including antioxidant, antimicrobial, and protective properties, while emphasizing the need for quality and safety assessment to mitigate possible adverse reactions.

This study found that deleting ceramide synthase 4 in skin epidermis stem cells disrupts hair follicle and skin barrier function, leading to immune responses similar to atopic dermatitis, due to imbalances in lipid composition affecting differentiation.

This study found that scanning electron microscopy revealed considerable abnormalities in hair morphology in MPS I, II, IIIA, and IIIB patients, potentially related to heparan sulfate accumulation.

This case report presented a 64-year-old Thai woman diagnosed with late-onset eruptive clear cell syringoma, and the authors highlighted a potential link between this condition and glucose metabolism abnormalities, suggesting the need for metabolic screening in similar elderly patients.

This study found that sebaceous-gland-derived glycerol significantly contributes to stratum corneum hydration in mice with sebaceous gland deficiencies.

This study reports new fluorogenic ceramidase substrates and highlights RBM14C24:1 as an efficient substrate for neutral ceramidase, while RBM15C18:1 is the best probe for measuring ACER1 and ACER2 activities, potentially aiding high-throughput screening for ceramidase inhibitors.

This study found that chondroitin sulfate levels were higher than hyaluronic acid in skin and hair follicle samples, with the highest concentration observed in prekeratin of hair follicles and wool fibers.

This study suggests that glycosaminoglycans, like hyaluronic acid obtained biotechnologically, are safe for topical cosmetic use, enhancing skin and hair conditions by supporting cell renewal, stimulating hair growth, and aiding in the treatment of scalp issues such as seborrhea and androgenetic alopecia.

In this study, researchers found that glycan profiles in epidermal stem cells differed between young and old mice, suggesting these changes may serve as molecular markers for aging.

This study suggests that tissue transglutaminase (TG2) may play a role in sebum production by regulating autophagy in sebaceous glands, offering potential targets for dermatological interventions.

This review discusses the protective roles of skin-resident immune cells in maintaining tissue homeostasis and facilitating wound healing, but reports no new experimental findings.

In this study, oral collagen peptides increased certain gene expressions related to epidermis development and the hair cycle in hairless mice skin, suggesting potential links to hair health.

The skin protects the body, regulates temperature, senses touch, and makes vitamin D.

This review discusses the formation and structure of the cornified cell envelope in the epidermis, highlighting biochemical pathways and genetic factors, but presents no new experimental results.

In this study, oral administration of strawberry guava extract promoted hair growth in both mice and humans, with active components like adenosine, fructose, digalactosyldiacylglycerol, and pedunculagin contributing by enhancing skin blood flow and activating dermal papilla cells.

In this randomized, placebo-controlled study, Kūlaris supplementation significantly improved quality of life for participants with mild-to-severe acne over 12 weeks, though no significant changes in general skin health measures were observed compared to placebo.

This review discusses the crucial role of sex hormones in maintaining and influencing skin health, suggesting ongoing research into hormonal treatments for skin conditions due to life stage changes.