Production of Glycosaminoglycans by Rat Hair Follicle Cells In Vitro

In 1981, a study on rat dermal tissue cultures, which included a significant number of hair follicle cells, demonstrated the production of glycosaminoglycans. These glycans were found both in cell aggregates and in material released from the cells. The study identified several glycosaminoglycan species, including hyaluronic acid, dermatan sulfate, chondroitin-4-sulfate, heparin, and heparan sulfate-C, with hyaluronic acid and dermatan sulfate being secreted into the culture medium. It was observed that the synthesis and sulfation patterns of these glycosaminoglycans changed over time in culture.