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Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Different PIN proteins affect plant root hair growth by changing how auxin is transported.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Animals that change color with the seasons mainly do so in response to daylight changes, but climate change is causing camouflage problems that may require evolutionary changes.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Skin changes can help diagnose and manage endocrine disorders like thyroid problems, diabetes, and adrenal gland conditions.

Human skin cells produce proenkephalin, which changes with environmental factors and skin diseases.

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.

Androgens slow hair growth by altering Wnt signaling in balding cells.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

The document concludes that alopecia areata is an autoimmune disease without a definitive cure, but treatments like corticosteroids are commonly used.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

Evaluate postmenopausal women with high androgen levels using medical history, physical exams, lab tests, and imaging to manage health risks.

Cats with atopic dermatitis often have severe, year-round itching and respond well to certain treatments.

Applying a specific inhibitor lightens skin and hair color.

Activating Nrf2 protects human hair follicles from oxidative stress and helps prevent hair growth inhibition.

Brain hormones significantly affect hair color and could potentially be used to prevent or reverse grey hair.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

Some medications can cause acne, and stopping these drugs is the main treatment.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.