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A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Sex hormones may influence COVID-19 severity, with males at higher risk, and certain hormone therapies could potentially treat the virus.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Different PIN proteins affect plant root hair growth by changing how auxin is transported.

The cornified envelope is crucial for skin's barrier function and involves key proteins and genetic factors.

RNA delivery is best for in-body use, while RNP delivery is good for outside-body use. Both methods are expected to greatly impact future treatments.

The protein RSL4 is crucial for making root hairs longer by controlling genes related to cell growth.

The document concludes that careful design of genetic fate mapping experiments is crucial for accurate cell lineage tracing in mice.

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

Increased HIF-1α is linked to the inflammation and severity of hidradenitis suppurativa, suggesting treatments that lower HIF-1α could help.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

Researchers found a gene in hamsters that responds to male hormones and may be indirectly controlled by them.

Dexamethasone affects hair growth by altering levels of proteins that either promote or inhibit hair follicle growth.

Jagged-1 in skin Tregs is crucial for timely wound healing by recruiting specific immune cells.

Vitamin D receptor is important for regulating hair growth and wound healing in mice.

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

Blocking a specific enzyme can reduce the negative impact of stress hormones on hair growth cells.

TGF-β2 plays a key role in human hair growth and development.

The Siah1 and Siah2 genes are active in mouse skin development and hair growth, especially right after birth.

Keratin 15 expression in skin cells is regulated by two mechanisms involving PKC/AP-1 and FOXM1.

Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.

Certain miRNAs might be involved in a hair loss condition called frontal fibrosing alopecia and could possibly help in its diagnosis.

The study found that sweat glands normally suppress immune responses, but this is disrupted in certain skin diseases, possibly contributing to their development.

Researchers created human cells that can turn into sebocytes, which may help study and treat skin conditions like acne.

Finasteride helps female-pattern hair loss.