The Role of Dexamethasone in Mediating the Contradictory Effects of Wnt Antagonists SFRP2 and SFRP3 on Human Hair Follicle Growth

    October 2023 in “ Scientific reports ”
    Ons Ben Hamida, Moon Kyu Kim, Mi Hee Kwack
    Studysummary In this study, researchers found that the synthetic stress hormone dexamethasone caused opposite effects on hair growth-related proteins, reducing SFRP2 and increasing SFRP3, which respectively stimulate and inhibit hair follicle cell proliferation in human dermal papilla cells.
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    Research cited in this study 9

    1. Dexamethasone, a Synthetic Glucocorticoid, Induces the Activity of Androgen Receptor in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2022
    2. Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth International Journal of Cosmetic Science · 2018
    3. SFRP2 Augments Wnt/β-Catenin Signalling in Cultured Dermal Papilla Cells Experimental Dermatology · 2016
    4. Effects of Glucocorticoid on Human Dermal Papilla Cells In Vitro The Journal of Steroid Biochemistry and Molecular Biology · 2012
    5. Hair Follicle as a Target of Stress Hormones and Autoimmune Reactions Journal of Dermatological Science · 2010
    6. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    7. Neuroimmunology of Stress: Skin Takes Center Stage Journal of Investigative Dermatology · 2006
    8. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
    9. The Secret Life of the Hair Follicle Trends in genetics · 1992