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Non-viral vectors show promise for safe and effective CRISPR/Cas9 gene editing in treating diseases.

This study cataloged several long non-coding RNAs and microRNAs in cashmere goat dermal papilla cells, suggesting these non-coding RNAs may play a role in hair follicle stem cell activation and hair growth.

This study found that blood and milk somatic cells show promise as matrices for monitoring illicit recombinant bovine somatotropin use in dairy cattle through gene-expression assays.

This study found that a solution containing 0.5% Camellia japonica placenta extract increased scalp moisture and reduced sebum content, dead keratin, and erythema in adult females, suggesting potential as a scalp treatment.

This study found that sebaceous gland-derived cutaneous adnexal carcinomas exhibited the highest frequency of genomic alterations compared to other tumor types.

This study identified TGFβ-2 as a potential driver of progenitor cell loss in hair follicles from early androgenetic alopecia scalps, suggesting its role in the condition's molecular disturbances.

This study found that delivering math1 via an adenovector led to vestibular hair cell regeneration and improved balance function in ototoxin-treated adult mice.

This study found that nonionic liposomes were the most effective vehicle for delivering reporter genes into the skin of rat pups, compared to other liposome and nonliposome formulations.

This review discusses various gene therapy and non-viral delivery methods to promote angiogenesis for chronic wound healing, but it reports no new clinical results.

This review discusses advancements in gene delivery to hair follicles and suggests potential gene therapy applications for treating hair loss, but it reports no new experimental results.

This review covers recent developments in inner ear therapeutics and gene delivery methods but reports no new clinical results; it highlights potential strategies for treating hearing and balance disorders.

Gene therapy shows promise for enhancing physical traits but faces ethical, safety, and regulatory challenges.

This meeting report discusses the first symposium on natural gene therapy for skin, preceding the 41st annual meeting of the European Society for Dermatological Research, and reports no new experimental findings.

This study reported that molecules from Zebrafish embryo cell differentiation can counteract neurodegeneration, regenerate tissues, and potentially reverse hair follicle damage in androgenetic alopecia.

In this study, a plant extract from Northeastern Turkey demonstrated potential for preventing hair loss by downregulating inflammation and androgen production and promoting hair growth in HaCaT cell models.

In this study, researchers found that hypoxic preconditioning significantly improved the regenerative potential of aged adipose-derived mesenchymal stem cells, enhancing their growth, differentiation, and pro-angiogenic capabilities, suggesting a promising strategy for autologous regenerative medicine applications.

This study suggests that administering SH-MSCs gel might decrease IL-6 expression and increase TGF-β expression in alopecia-like rats, indicating potential for alopecia therapy.

This study found that systemic treatment with DS77754007, a KLK5 inhibitor, improved skin symptoms in a mouse model of Netherton Syndrome more effectively than certain antibody treatments, suggesting KLK5 inhibition as a promising therapeutic approach for this condition.

In this study, researchers identified nine FDA-approved drugs that activate the Wnt signaling pathway, with Aminoacridine, especially when combined with Minoxidil, showing promising effects on hair and nail growth in mice, suggesting potential treatments for hair and nail loss pending further clinical trials.

This study found that a newly identified mutation in the hairless gene in mice led to decreased Hr mRNA levels and changes in gene expression related to hair follicle development.

This review explains methods for studying chromatin variation at the single-cell level using scATAC-seq and discusses integrating these measures with other omics platforms but reports no new results.

This review discusses the association between androgen receptor gene polymorphism and PCOS, reporting mixed findings on whether shorter or longer CAG repeats are linked to the disorder; it provides no new results and calls for further studies.

This review highlights exosomes as a promising treatment for skin damage from UV light, infrared radiation, burns, and disorders due to their anti-inflammatory properties, ability to induce macrophage polarization, and acceleration of skin repair and regeneration.

This study found that nestin-expressing hair follicle-derived cells express higher levels of certain neurotrophic factors and neural markers, indicating potential for neuroregenerative therapy applications.

This study found that a chemically modified small-interfering RNA candidate, AR-27 E-Chol, effectively stimulated hair regrowth and reduced androgen receptor gene expression in a mouse model of androgenetic alopecia, indicating its potential as a novel therapeutic approach.

In this study using animal models, umbilical cord stem cell conditioned media combined with oral anti-androgens improved hair regeneration in androgenetic alopecia, enhancing hair follicle cycles and reducing inflammation, suggesting potential as a promising therapy.

This study identified at least four distinct fibroblast populations in adult human skin, each with unique functional properties, suggesting potential therapeutic applications for wound healing and fibrosis-related diseases.

In this single-cell transcriptomic study, researchers analyzed AA scalp samples and found distinct immune and nonimmune cell activation patterns, with elevated TH1/TH2 and JAK/STAT markers potentially contributing to hair follicle immune privilege disruption and disease severity.

This review summarizes existing knowledge on the role of FOXN1 as a key regulator of thymic epithelial cell lineage and function, reporting no new experimental results.

This study found that early passage dermal papilla cell-derived extracellular vesicles, combined with specialized medium, helped adipose-derived stem cells develop dermal papilla-like properties.