Tracing Recombinant Bovine Somatotropin Use Through Gene Expression in Blood, Hair Follicles, and Milk Somatic Cells: A Matrix Comparison

    July 2018 in “ Molecules ”
    Alexandre Lamas, Patricia Regal, Beatriz Vázquez, José Manuel Miranda, Alberto Cepeda, C. M. Franco
    TLDR Gene expression in milk cells and blood can help detect illegal rbST use in cows.
    The study evaluated the potential of using gene expression in milk somatic cells, blood, and hair follicles to detect the illicit use of recombinant bovine somatotropin (rbST) in dairy cattle, which is banned in the EU. It involved 6 rbST-treated cows and 3 controls, with samples collected before and after rbST administration. The study found that RNA quality was higher in blood and hair follicles, and significant gene expression differences were observed, particularly in milk somatic cells and blood. Genes such as CCND1, IL-1β, TNF, and IGF-1R were identified as potential biomarkers for rbST treatment, suggesting these matrices could be used for routine rbST control.
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