3 citations
,
April 2022 in “Bioengineering” This review discusses pre-clinical research on ultrasound-mediated sonoporation for tissue regeneration and reports no clinical results; the authors suggest the method is safe and highlight challenges to clinical translation.
January 2022 in “Sustainable development goals series” The document concludes that significant investment in agricultural innovation is necessary to achieve global food security and nutrition.
14 citations
,
January 2024 in “Theranostics” In this study involving a mouse model, researchers reported that intranasal delivery of protein-based CRISPR/dCas9 nanoparticles targeting the gene *Sirt1* reduced cerebral edema and increased survival following ischemic stroke, with no significant toxicity observed.
9 citations
,
May 2012 in “PLOS ONE” This study found that integrin-linked kinase is crucial for various epidermal functions, including differentiation and barrier formation, and also plays a previously unreported role in melanocyte development and function.
1 citations
,
October 2023 in “Frontiers in Oncology” This study presented cases where potentially significant germline variants were unexpectedly found during genomic profiling for myeloid malignancies, discussing the challenges in genetic counseling and management, especially when variants don't match the patient's condition.
December 2024 in “International Journal of Molecular Sciences” This study observed that treating basal and squamous cell carcinoma cells with platelet-rich fibrin significantly reduced cell viability and increased apoptosis-associated gene expression, suggesting potential use as adjunctive therapy for localized nonmelanoma skin cancers.
5 citations
,
May 2022 in “Biomedicines” This study found that the green alga Botryococcus terribilis and its novel compounds significantly promoted hair growth marker gene expression in hair follicle dermal papilla cells without cytotoxic effects.
February 2026 in “International Journal of Molecular Sciences” This study investigated the photoprotective properties of Brazilian pepper tree extract against UV-induced damage in skin cells, reporting that it enhanced expression of genes relevant to skin health and showed superior activity compared to standard antioxidants.
2 citations
,
June 2024 in “Skin Research and Technology” This study found that low-level laser stimulation activates the Wnt signaling pathway, promoting hair follicle stem cell regeneration and accelerating wound healing.
January 2026 in “Current Issues in Molecular Biology” This paper reviews the emerging role of FGF-7 signaling in hair regeneration, highlighting its potential as a target for new therapies despite limited clinical trial data.
4 citations
,
April 2018 in “Journal of Investigative Dermatology” This study suggests that hydroxypinacolone retinoate (HPR) may be an effective alternative to tretinoin for anti-aging skin treatments, offering similar collagen production benefits without increased skin irritation.
1 citations
,
November 2005 in “Journal of Andrology” This meeting abstract details various lectures and workshops from the 30th Annual Meeting of the American Society of Andrology, including findings on genetic and physiological factors affecting male fertility, but reports no new clinical results.
In this study, researchers developed a computational method called iEdgePathDDA that prioritizes anticancer drug candidates by analyzing changes in gene interactions, demonstrating superior performance compared to existing methods across colorectal, breast, and lung cancer datasets.
8 citations
,
July 2020 in “BMC genomics” In this study, ceruloplasmin and keratin 4 were identified as markers that differentiate between growing and resting phases in cashmere goat hair follicles, with keratin 4 being a potential marker for the onset of a new hair cycle.
July 2025 in “Journal of Investigative Dermatology” Reduced AhR signaling in HS tunnels leads to persistent inflammation and microbial imbalance.
15 citations
,
February 2021 in “Cells” This study concluded that using human umbilical cord blood mononuclear cells transfected with VEGF and FGF2 genes enhances skin wound healing in rats, demonstrating greater wound revascularization compared to controls.
8 citations
,
February 2025 in “Cell Systems” This study developed a genetic toolbox to engineer Cutibacterium acnes for dermal applications, successfully creating a strain that secretes antioxidants to reduce oxidative stress in a UV stress model.
34 citations
,
August 2016 in “Scientific Reports” This study validated a protocol for inducing surface ectoderm differentiation from human induced pluripotent stem cells and highlighted the role of TGFβ signaling pathways in this process.
24 citations
,
August 2021 in “Scientific Reports” This study found that non-thermal atmospheric pressure plasma may stimulate hair growth through activation of the Wnt/β-catenin signaling pathway, suggesting it could be a potential non-pharmacological treatment for alopecia.
9 citations
,
August 2024 in “International Journal of Molecular Sciences” This review explores epidermolysis bullosa simplex subtypes caused by mutations in KRT5 or KRT14 and summarizes gene expression patterns and molecular mechanisms, without presenting new experimental results.
January 2025 in “Clinical Cosmetic and Investigational Dermatology” This study found that pediatric alopecia areata patients with atopic predisposition showed heightened immune and inflammatory responses, including significant immune cell infiltration, compared to adults and healthy controls.
222 citations
,
September 2016 in “JCI insight” This research overview highlights that although JAK inhibitors show promise as potential treatments for alopecia areata based on recent insights into the disease mechanism, their efficacy has not yet been thoroughly evaluated in a systematic manner.
65 citations
,
November 2012 in “Tissue Engineering Part B-reviews” This review discusses the biology of hair follicle stem cells and highlights their potential for applications in regenerative medicine, drug, and gene delivery, but reports no new clinical results.
28 citations
,
March 2019 in “Journal of Dermatological Science” This review discusses methods for evaluating hair growth-promoting effects of candidate substances for androgenetic alopecia, focusing on cell assays, organ cultures, and animal models, and reports no new results.
14 citations
,
November 2020 in “International Journal of Molecular Sciences” This review article summarizes the potential role of advanced medical therapies—using genes, cells, and/or tissue engineering—in treating various types of alopecia, by examining clinical research, basic studies, and ongoing trials.
13 citations
,
January 2010 in “Advances in Biochemical Engineering / Biotechnology” This review covers various aspects of hair biology, pigmentation, and development, focusing on genetic and biochemical modulation of hair follicle components but reports no new findings.
10 citations
,
March 2022 in “Communications biology” In this study, researchers found that non-invasive analysis of skin surface lipid RNAs revealed alterations in gene expression patterns associated with atopic dermatitis, suggesting its potential for understanding skin disease pathophysiology.
9 citations
,
December 2021 in “Androgens” This review explores how androgen administration might help alleviate inflammation and mitochondrial impairment in traumatic brain injury but reports no new experimental findings, calling attention to the need for further investigation.
9 citations
,
February 2019 in “BMC cancer” This study found that M30 may protect against cyclophosphamide-induced alopecia in mice by enhancing hair growth and preventing abnormal hair, suggesting its potential as a treatment.
1 citations
,
September 2019 in “Journal of Investigative Dermatology” In this study, researchers used a CRISPR-based method to correct mutations in the COL7A1 gene in stem cells from RDEB patients, restoring normal collagen expression in engineered skin grafts in mice.