Spatial Transcriptome Profiling Reveals TGFβ-2 in Hair Follicle Progenitor Cells Is a Potential Driver of Androgenetic Alopecia

April 2023 in “ Journal of Investigative Dermatology ”

S. Charoensuksira, J. Pongklaokam, S. Tantiwong, S. Hanvivattanakul, P. Surinlert, S. Ponnikorn

androgenetic alopecia spatial transcriptome profiling hair follicle progenitor cells transforming growth factor beta TGF-β TGFB2 immunohistochemistry AGA TGFβ-2

TLDR TGFβ-2 may cause hair loss in androgenetic alopecia.

This study investigates the molecular mechanisms behind progenitor (PG) cell loss in androgenetic alopecia (AGA) using spatial transcriptome profiling of human scalp samples. Researchers used NanoString GeoMxTM Whole Transcriptome Atlas to compare gene expression in PG regions from early AGA and control scalps, identifying 197 differentially expressed genes. Pathway enrichment analysis highlighted transforming growth factor beta (TGF-β) production as a significantly disturbed process, with TGFB2 identified as a potential upstream regulator. Immunohistochemistry confirmed increased TGFβ-2 in AGA samples, suggesting TGFβ-2 as a potential driver of PG cell loss in AGA.

View this study on jidonline.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community The Real Cause Of Androgenetic Alopecia

in Research/Science 669 upvotes 2 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Androgenetic alopecia - I want your honest opinion

in Female 33 upvotes 2 years ago

A female user's diagnosis of androgenetic alopecia, and the advice shared in response which suggests taking spironolactone and minoxidil together to prevent hair loss.

community Androgenetic Alopecia stage 2: Did all you of you straight away start taking Fin and/or Min? My dermatologist has started me on supplements.

in Treatment 5 upvotes 2 years ago

The user is hesitant to start Fin and Min due to their long-term commitment and is currently on a 2-month supplement course. Another user suggests that the supplements are ineffective and recommends using Fin and Min for androgenetic alopecia.

community COMPLETE OVERVIEW of the Treatment of androgenetic alopecia in men

26 upvotes 10 years ago

Male androgenetic alopecia is commonly treated with topical minoxidil and oral finasteride, both requiring continuous use. Other options include hair restoration surgery, dutasteride, light therapy, and camouflaging agents.

community Can a folate deficiency make androgenetic alopecia worse?

in Treatment 1 upvotes 10 months ago

The user is treating androgenetic alopecia with finasteride and discovered a folic acid deficiency. They are asking if curing the deficiency can worsen or improve their hair condition.

Related Research

1 / 1 results

The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells

research The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells

35 citations, July 2018 in “Cell Reports”

The study found that a specific area of the hair follicle helps start hair growth by reducing the blocking effects on certain cells and controlling growth signals.