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Single Cell Transcriptome Profiling of Human Interfollicular Epidermis Reveals Robust Heterogeneity and Divergent Differentiation Lineages

research Single Cell Transcriptome Profiling of Human Interfollicular Epidermis Reveals Robust Heterogeneity and Divergent Differentiation Lineages

April 2018 in “Journal of Investigative Dermatology”

The human skin's outer layer has more variety in cell types and development paths than previously thought.

research Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis

21 citations, January 2018 in “Journal of Investigative Dermatology”

Rats can't grow new hair follicles after skin wounds, unlike mice, due to differences in gene expression and response to WNT signaling.

research Single-Cell Transcriptome Sequence Profiling on the Morphogenesis of Secondary Hair Follicles in Ordos Fine-Wool Sheep

1 citations, January 2024 in “International journal of molecular sciences”

The research identifies genes linked to wool quality in sheep and provides insights to improve wool production.

research The Developmental Basis of Fingerprint Pattern Formation and Variation

44 citations, February 2023 in “Cell”

Fingerprints form uniquely before birth due to specific genetic pathways and local signals.

research Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature

10 citations, December 2021 in “Frontiers in cell and developmental biology”

The research identified genes that explain why some sheep have curly wool and others have straight wool.

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community DHT and 5AR respect post, it's importance within the brain

DapperDHT in Research/Science 111 upvotes 11 months ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community Kintor has announced the results for their human Phase I trials of GT20029

poiuytrewq_poiuytrew in Research/Science 253 upvotes 2 years ago

The conversation discusses the potential of a new hair loss treatment, GT20029, which may prevent hair loss by destroying androgen receptors on the scalp. Users express hope for the treatment's success and speculate on its usage routine, effectiveness, and possible side effects.