May 2026 in “International Journal of Dermatology” This study found that serum 3α-androstanediol glucuronide levels were higher in Indian women with female pattern hair loss and correlated with the severity of the condition.
In this study, Origanum vulgare extracts showed antioxidant activity and increased insulin-like growth factor-1 expression without causing cytotoxicity in human hair dermal papilla cells.
January 2022 in “Drug Delivery” This study investigated a finasteride and oregano oil-loaded nano-cubosome gel formulation, finding it enhanced drug release and skin permeation and demonstrated synergistic antibacterial effects, suggesting potential for treating alopecia areata.
August 2025 in “JOURNAL OF EXPERIMENTAL ZOOLOGY INDIA” This study reported that a spray containing Origanum marjoram essential oil significantly improved hair regrowth, dermal thickness, weight, and lymphocyte levels in rabbits with cyclophosphamide-induced alopecia, suggesting its potential as a natural alternative for hair loss treatment.
4 citations
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September 2020 in “Andrologia” This study found that Origanum vulgare extract improved testicular structure and function in mice against finasteride-induced damage by enhancing antioxidant defense and modulating gene expression related to apoptosis.
March 2020 in “Upravlìnnâ, ekonomìka ta zabezpečennâ âkostì v farmacìï” This study developed quality control methods for the "Flavosterol" emulgel, which met the required quality standards and is intended for the prevention and treatment of androgenetic alopecia.
March 2023 in “Reactions Weekly”
October 2024 in “International Journal For Multidisciplinary Research” This review highlights that Wedelolactone, a compound in Eclipta prostrata, appears to be a potent antioxidant and selective modulator of proteins linked to chronic diseases, suggesting further research into its pharmacological effects is warranted according to the examined data.
1 citations
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February 2024 in “Peer Review” This study reviewed the use of rosemary essential oil combined with photobiomodulation for treating androgenetic alopecia, highlighting the potential benefits of rosemary's antioxidant and vasodilatory properties alongside enhanced cellular processes from photobiomodulation.
2 citations
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March 2005 in “Journal of the American Academy of Dermatology” Equol may help with antiaging and skin health by boosting collagen and blocking certain hormones.
2 citations
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April 2021 in “Asian pacific Journal of Tropical Biomedicine” This study found that Origanum vulgare extract significantly ameliorated finasteride-induced liver and kidney damage in mice by improving biochemical indices, reducing inflammation, and enhancing antioxidant status in a dose-dependent manner.
50 citations
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December 2022 in “Food Chemistry Advances” This review discusses diosgenin's potential benefits for several chronic diseases and emphasizes extraction and quantification techniques, but reports no clinical findings.
December 2025 in “Fullerene Journal of Chemistry” This study investigated the potential of nutmeg-derived phytochemicals as anti-alopecia agents using molecular docking and simulations, finding that geranylgeraniol exhibited significant binding stability and potential efficacy against androgenetic alopecia comparable to finasteride and superior to minoxidil.
November 2025 in “Clinical and Translational Allergy” This study developed a consensus document to guide danazol discontinuation in hereditary angioedema patients, enhancing the standardization and safety of treatment protocols.
8 citations
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April 1991 in “European journal of endocrinology” This study found that cyproterone acetate significantly reduced both serum 3α-AdiolG levels and hirsutism scores in women with idiopathic hirsutism, PCOS, or 21-hydroxylase deficiency, suggesting its effectiveness in treating excessive hair growth.
May 2026 in “Frontiers in Pharmacology” In this study, DOP treatment improved hair regrowth in androgenetic alopecia by altering local steroid metabolism and follicular morphology.
This study found that an ethanolic extract of Ganoderma lucidum, especially at 15mg/kg, may promote hair growth in a rat model of testosterone-induced alopecia, showing effects comparable to minoxidil.
January 1995 in “Revista de arqueología” In this study, the vitamin D analogues 1 alpha,25-dihydroxy-vitamin D3 and calcipotriol were found to thin the living cell layer and affect differentiation marker expression in organotypic cultures of human outer root sheath cells.
2 citations
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October 2020 in “Drug Discoveries & Therapeutics” This study observed that Althaea officinalis gel increased fibroblast populations, hair follicles, and vessel diameter in rat wounds, suggesting it might aid wound healing, though further clinical studies are needed.
May 2019 in “Ukraïnsʹkij bìofarmacevtičnij žurnal” This study observed that the cream-mask and gel-mask with Serenoa repens and Sophora japonica applied to a rat model of androgenic alopecia stimulated hair follicle growth similarly to a reference minoxidil treatment.
1 citations
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August 2025 in “Molecules” This review synthesizes research on hederagenin's anticancer and anti-inflammatory potential, emphasizing chemical modifications to enhance its bioactivity, but reports no new experimental findings.
23 citations
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October 2008 in “Journal of medicinal chemistry” This study suggests that PF-0998425 is an effective androgen receptor antagonist for sebum control and androgenetic alopecia with rapid metabolism reducing the risk of systemic side effects.
4 citations
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April 2022 in “Evidence-based Complementary and Alternative Medicine” This study found that dracorhodin perchlorate improved wound healing in diabetic rats by regulating the TLR4 pathway and related inflammatory factors.
19 citations
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June 2010 in “Journal of acupuncture and meridian studies” This study found that emodin from Polygonum multiflorum showed 5alpha-reductase inhibitory activity, which was more potent than alizarin but less potent than riboflavin.
January 2025 in “International Journal of Dermatology Research” In this study, a herbal preparation inhibited the conversion of testosterone to DHT and its binding on hair roots in vitro, suggesting potential as an alternative treatment for androgenic alopecia without the safety concerns associated with finasteride.
August 2026 in “Journal of Drug Delivery Science and Technology” January 2006 in “Benzina: Revista d'excepcions culturals” This study observed that new trienone compounds consistently showed higher 5alpha-reductase inhibitory activity compared to corresponding dienones across various biological models.
66 citations
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October 1987 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study found that serum 3 alpha-diol G levels in women with idiopathic hirsutism correlated well with their clinical response to treatment, suggesting its usefulness in evaluating treatment outcomes.
February 2023 in “Journal of plant science and phytopathology” This review discusses the phytochemical and pharmacological properties of Jatropha dioica, highlighting its potential uses in traditional medicine and the need for more scientific validation of its effects.
5 citations
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November 2015 in “Journal of Enzyme Inhibition and Medicinal Chemistry” This study found that aliphatic ester moieties in 16-formyl-17-methoxy dehydroepiandrosterone derivatives increased their potency as 5α-reductase type 2 inhibitors in vitro compared to finasteride.