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This study found that Ganoderma lucidum extracts showed weak 5alpha-reductase inhibition but significantly inhibited prostate cell proliferation and testosterone-driven prostate growth in rats, suggesting potential as an ingredient for treating androgen-induced diseases.

In this study, researchers found that Ganoderma Lucidum extract and Ganoderic acid A significantly improved hair follicle growth and delayed hair loss progression, based on in vitro, ex vivo, and 24-week human clinical trials, suggesting potential as a therapeutic for androgenetic alopecia.

This study found that Ganoderma Lucidum extract and its active component, Ganoderic acid A, improved hair cell proliferation and growth factor expression in lab and clinical settings, demonstrating significant hair loss inhibition effects when used in shampoo and tonic formulations over 24 weeks.

In castrated rats, this study found that triterpenoids from Ganoderma lucidum inhibited both types of 5α-reductase and reduced prostate growth linked to testosterone but not dihydrotestosterone.

This review discusses the use of mushrooms and their bioactive compounds in cosmeceuticals and nutricosmetics and reports no new clinical findings, highlighting potential areas for future research and development.

This review explores the diverse health benefits and pharmacological properties of mushrooms, highlighting their potential use in cosmetics for antioxidant, anti-aging, and anti-hair loss effects due to their bioactive compounds.

This review discusses the role of inheritance, androgens, and microinflammation in androgenetic alopecia and suggests some plant-based folk remedies may help address these factors but reports no new clinical results.

This review discusses current therapeutic targets and treatments for androgenic alopecia but reports no clinical results; the authors highlight the challenge of developing multi-target drugs for effective treatment.

This study found that long-term use of triterpenoids from Ganoderma lucidum may improve brain function and alleviate aging-related issues in normal and Alzheimer's mouse models.

In this exploratory in vitro study, treatment with spermidine increased cell viability and altered gene expression in human epidermal keratinocytes, suggesting potential benefits to cellular health and function, though effects on mitochondrial markers were not significant.

In this study, germacrone from Curcuma aeruginosa showed anti-androgenic effects by inhibiting 5α-reductase, suggesting its potential as a lead compound for treating androgen-dependent disorders.

This article discusses the familiarity of identifying male androgenetic alopecia but presents no new research findings.

This review examines the role of steroidal inhibitors in treating prostatic diseases but presents no new clinical results.

This study found that Ganoderma lucidum extracts reduced prostate enlargement and improved symptoms in testosterone-treated rats, suggesting potential benefits for managing benign prostatic hyperplasia.

This review discusses the therapeutic potential of Ganoderma lucidum's secondary metabolites, noting their diverse health benefits, such as anticancer and antioxidant effects, without presenting new experimental results.

This review summarizes recent advancements in steroidal 5α-reductase inhibitors for benign prostatic hyperplasia and reports no new clinical results.

This review highlights the challenges in screening for steroid 5 alpha-reductase inhibitors and discusses significant variability in the effectiveness of finasteride and dutasteride, calling for standardized testing methods to develop safer, more specific inhibitors from herbal preparations.

Ganoderma lucidum extract may help treat stress-related hair loss.

This study identified two potent 5α-reductase inhibitors from Tectona grandis leaves, and suggests that ethanol is a preferable solvent for extracting these compounds, which are potential ingredients for hair loss treatments.

In this study, Ganoderma lucidum extract was found to significantly inhibit 5alpha-reductase activity and testosterone-induced prostate growth in rats, suggesting potential use for treating benign prostatic hyperplasia.

This study found that the water extract of Bituminaria bituminosa demonstrated the highest antioxidant activity and α-glucosidase inhibition among tested extracts, but no cholinesterase or tyrosinase inhibition.

This study found that Avicennia marina extract significantly inhibited 5α-reductase type 1 activity in human hair dermal papilla cells, suggesting its potential use for treating androgenic alopecia.

This review highlights how natural products with antioxidant properties can modulate the Wnt signaling pathway, potentially influencing various pathological conditions such as cancer, stroke, and regenerative medicine. It also addresses controversies in the compounds' mechanisms across different models and suggests research directions for future studies.

This research highlights selenium's critical roles in various biological processes and underscores the potential health impacts of both its deficiency and excess, including increased mortality risk, poor immune function, and neurological issues.

This study reports that a novel nanolipogel with moderate rigidity (NLG-2.5) enhances transdermal delivery of fucosterol, displaying superior permeability, targeting hair follicles, and promoting hair growth in androgenetic alopecia model mice by inhibiting inflammation and androgen pathways and promoting angiogenesis.

This in-silico study identified several compounds as potential Vitamin D Receptor agonists, with Dolichosterone showing the strongest binding energy.

This study concluded that serum Adiol-G levels generally parallel testosterone levels and, therefore, do not effectively serve as a marker of peripheral androgen excess in women with androgenic symptoms.

This study found that bolandiol increased lean body mass and bone mineral density in castrate adult male rats, exhibiting tissue selectivity and acting through multiple receptor pathways with less potency compared to other androgens.

This study reported that after 7.5 months of treatment, topical Alfatradiol significantly increased anagen hair rates in women and men with androgenetic alopecia, with minimal side effects.

This study found that administering gingerol improved survival and reduced organ damage in mouse models of chronic graft-versus-host disease by modulating T cell differentiation and inflammatory cytokines, suggesting a novel therapeutic approach for steroid-refractory cases.