Strange February Mornings: Pauline Fondevila

    January 2006 in “ Benzina: Revista d'excepcions culturals ”
    Neus Miró
    TLDR Trienones are more effective at inhibiting the enzyme linked to hair loss than dienones.
    The study aimed to synthesize new steroidal compounds based on the progesterone skeleton to inhibit the enzyme 5alpha-reductase, which is implicated in androgen-dependent diseases like androgenic alopecia. The research focused on creating derivatives such as 16beta-methyl-pregnadiene-3,20-diones and 16beta-phenyl-pregnadiene-3,17a-dione, which were tested in various biological models. The trienones (compounds 30, 31, and 43-46) consistently demonstrated higher 5alpha-reductase inhibitory activity compared to dienones (compounds 27, 32, 33, and 38-42). The study suggested that the trienones' coplanar structure allowed for faster reaction with the enzyme, leading to greater inhibition through an irreversible Michael type addition.
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      community Is this broscience? From More Plates, More Dates

      in Research/Science  21 upvotes 2 years ago
      The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

      community I think we all hop on estrogen. It's the only angle

      in Satire  83 upvotes 1 year ago
      The conversation humorously discusses hair loss treatments, including Minoxidil, finasteride, RU58841, and topical 17 alpha estradiol, with some users joking about transitioning to female to avoid baldness. The overall tone is satirical, emphasizing self-acceptance and the lengths people might consider for hair restoration.

      community Testosterone and hair loss seeming irrelevance

      in Research/Science  83 upvotes 2 years ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

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