Ethanolic Extract of Ganoderma Lucidum for Androgenic Alopecia Treatment in Testosterone-Induced Bald Rats
January 2023
Studysummary This study found that an ethanolic extract of Ganoderma lucidum, especially at 15mg/kg, may promote hair growth in a rat model of testosterone-induced alopecia, showing effects comparable to minoxidil.
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The study investigated the hair growth-promoting properties of an ethanolic extract of Ganoderma lucidum (EEGL) on testosterone-induced alopecia in rats. Five groups of rats (each group n = 6) were tested: a negative control group, a positive control group, a group treated with testosterone plus minoxidil 2%, and two groups treated with testosterone and EEGL at doses of 10 mg/kg and 15 mg/kg respectively. After 21 days, the anagen/telogen (A/T) ratio, follicular density, and hair length were all higher in the standard, EEGL 10mg/kg, and EEGL 15mg/kg treatment groups compared to the positive control group. The study concluded that EEGL was able to promote hair growth through the return of normal parameters, with EEGL15mg/kg producing more favorable outcomes than EEGL10mg/kg. The outcomes were equivalent to those of Minoxidil 2% solution, a commonly recommended drug used to encourage hair growth in persons with androgenetic alopecia.
