Ethanolic Extract of Ganoderma Lucidum for Androgenic Alopecia Treatment in Testosterone-Induced Bald Rats
January 2023
TLDR Ganoderma lucidum extract promotes hair growth in bald rats, with higher doses producing better results, similar to the effects of Minoxidil 2%.
The study investigated the hair growth-promoting properties of an ethanolic extract of Ganoderma lucidum (EEGL) on testosterone-induced alopecia in rats. Five groups of rats (each group n = 6) were tested: a negative control group, a positive control group, a group treated with testosterone plus minoxidil 2%, and two groups treated with testosterone and EEGL at doses of 10 mg/kg and 15 mg/kg respectively. After 21 days, the anagen/telogen (A/T) ratio, follicular density, and hair length were all higher in the standard, EEGL 10mg/kg, and EEGL 15mg/kg treatment groups compared to the positive control group. The study concluded that EEGL was able to promote hair growth through the return of normal parameters, with EEGL15mg/kg producing more favorable outcomes than EEGL10mg/kg. The outcomes were equivalent to those of Minoxidil 2% solution, a commonly recommended drug used to encourage hair growth in persons with androgenetic alopecia.
