4 citations
,
September 2020 in “Andrologia” This study found that Origanum vulgare extract improved testicular structure and function in mice against finasteride-induced damage by enhancing antioxidant defense and modulating gene expression related to apoptosis.
3 citations
,
March 2024 in “Cureus” This study found that PRP may effectively reduce TMJ pain and improve jaw function and quality of life in young adults with mild TMD.
1 citations
,
May 1999 in “Journal of Oral and Maxillofacial Surgery” Patients with mandible reconstruction had better quality of life and function than those with soft-tissue reconstruction.
December 2023 in “Journal of nutritional science and vitaminology” This study in mice found that a zinc-deficient diet suppressed body weight gain and increased kidney and cecum tissue weight without decreasing serum alkaline phosphatase activity. Additionally, zinc deficiency caused alopecia and intestinal changes in C57BL/6J mice, potentially affecting nutritional status.
March 2024 in “medRxiv (Cold Spring Harbor Laboratory)” This study found that faster algorithms for inferring ancestry in genomic data can better capture historical and functional insights into genome variation than traditional methods in large datasets like the UK Biobank.
January 2022 in “International Journal of Science and Research (IJSR)” This review discusses the biochemical and psychological impacts of polycystic ovary syndrome on immune functions against COVID-19 but reports no new clinical results.
April 2017 in “Journal of Investigative Dermatology” The researchers reported that iPSCs derived from Sendai virus reprogrammed blood cells can mature into functional keratinocytes for up to 60 days, potentially offering new approaches for DEB treatment.
150 citations
,
August 1992 in “Genes & Development” This study reported that transgenic mice with targeted TNF alpha expression in keratinocytes showed impaired weight gain, retarded hair growth, and skin changes, leading to cachexia and necrosis.
55 citations
,
April 2010 in “Cancer and Metastasis Reviews” This article discusses the complex role of TGFβ in cancer progression, highlighting its dual function as both a tumor suppressor in early stages and a promoter in later stages, without reporting new results.
50 citations
,
January 2016 in “The FEBS journal” This review discusses the various roles of RANK signaling in bone remodeling, immune function, and epithelial differentiation, highlighting its potential involvement in cancer mechanisms; it reports no new clinical results.
49 citations
,
March 2019 in “Journal of Investigative Dermatology” This review discusses dermal white adipose tissue's roles in skin immunity, highlighting its antimicrobial function and interactions with other immune cells, but reports no new clinical results.
21 citations
,
January 2019 in “Experimental dermatology” This review explores how low-energy He-Ne laser therapy may stimulate repigmentation in vitiligo by affecting mitochondrial pathways and melanocyte function, but does not report new clinical results.
14 citations
,
August 2009 in “Cancer epidemiology” This study found that AHCC significantly reduced alopecia caused by Ara-C in neonatal rats and improved liver function affected by 6-MP and MTX in mice.
11 citations
,
January 2022 in “Theranostics” In this study, Wnt4 was identified as a key factor in cardiac repair, where its regulation in cardiac fibroblasts improved cardiac function and revascularization following ischemic reperfusion injury.
3 citations
,
January 2023 in “PloS one” In this study, hair-follicle-associated pluripotent stem cell implantation improved functional recovery and reduced inflammation in a mouse model of intracerebral hemorrhage.
April 2026 in “Frontiers in Cell and Developmental Biology” This literature review suggests that hair cell loss in hearing loss is often secondary to preceding morphological and functional defects in hair cells, indicating that interventions should focus on hearing preservation before significant hair cell loss occurs.
November 2024 in “Malaysian Journal of Microbiology” In this study, researchers found varying levels of multiple autoantibody types among thyroid disorder patients, with 84.84% of those with immunological hypothyroidism reporting symptoms like weight gain and lethargy, whereas 81.81% of those with immune hyperthyroidism experienced hair loss.
August 2023 in “Gadua Journal of Pure and Allied Science” This study on diabetic rats reported that Ziziphus spina-christi ethanol leaf extract significantly reduced blood glucose levels and improved liver and kidney function, suggesting possible benefits in managing diabetes symptoms in this animal model.
November 2018 in “Atlas of genetics and cytogenetics in oncology and haematology” The review discusses the diverse roles of WNT10B in mammary gland development, immune function, and its potential implications in cancer and regenerative processes, with no new experimental results.
354 citations
,
February 2011 in “Genes & Development” This study found that abolishing H3K27me3 in mouse skin by targeting Ezh2 and Ezh1 affects hair follicle development and epidermal behavior, revealing functional differences between these tissues.
320 citations
,
December 2018 in “Frontiers in Immunology” This review explores how preconditioning mesenchymal stromal cells can impact their secretome's therapeutic potential in regenerative medicine, emphasizing immunomodulatory and regenerative functions, but provides no new clinical results.
260 citations
,
December 2012 in “Cold Spring Harbor Perspectives in Biology” This review discusses the significant role of Wnt signaling in skin development, homeostasis, and disease, highlighting recent advances in understanding its diverse functions, but reports no new experimental results.
237 citations
,
February 2016 in “Science Translational Medicine” This study found that many effects previously thought to be caused by circadian rhythm disruption in Bmal1 knockout mice are actually due to BMAL1's properties unrelated to its clock function.
163 citations
,
March 2012 in “BMC biology” This forum article in BMC Biology discusses evolving views on the concept of the stem cell niche, highlighting varied mechanisms and the need for better understanding of the niche's roles and functions.
140 citations
,
April 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that mice lacking the 1αOHase enzyme, which is responsible for producing a key vitamin D metabolite, showed impaired epidermal differentiation and delayed recovery of skin barrier function after disruption.
92 citations
,
September 2015 in “Journal of Lipid Research” This review discusses the roles of dermal white adipose tissue (dWAT) as an insulator, antibiotic, and regenerative tissue, highlighting its importance in systemic metabolism and immune function, but reports no new clinical results.
92 citations
,
November 2003 in “The Journals of Gerontology” This study indicated that while testosterone replacement in older men with low testosterone increases muscle mass and strength and reduces fat, its effects on physical function, disability, falls, or fractures remain unclear.
87 citations
,
January 2016 in “Development” This study suggests that the postnatal loss of hair follicle formation in wounds may be due to elevated Wnt/β-catenin activation in the dermis, affecting fibroblast function in mice.
81 citations
,
July 2008 in “The Journal of Clinical Endocrinology and Metabolism” This study found that cortisone reductase deficiency is caused by inactivating mutations in the H6PD gene, affecting cortisol metabolism by preventing 11β-HSD1 enzyme function.
75 citations
,
September 2017 in “Developmental biology” This review discusses circadian clock regulation in stem cells and its role in processes like neurogenesis, but reports no new results; the authors emphasize its significance in stem cell function across various tissues.