research Wnt/β-Catenin Signaling: Function, Biological Mechanisms, and Therapeutic Opportunities
The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.
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840-870 / 1000+ results research Understanding, Recognizing, and Managing Toxicities of Targeted Anticancer Therapies
Targeted anticancer therapies can cause severe side effects similar to traditional chemotherapy, but with different types.
research BRAF Inhibitor Dabrafenib in Patients with Metastatic BRAF-Mutant Thyroid Cancer
Dabrafenib was effective and well tolerated in treating thyroid cancer with a specific mutation.
research Intracrine Androgen Biosynthesis, Metabolism, and Action Revisited
The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.
research Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts During Wound Healing
Dermal fibroblasts have adjustable roles in wound healing, with specific cells promoting regeneration or scar formation.
research Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2
Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.
research Advances in Chitosan-Based Nanoparticles for Drug Delivery
Chitosan, a natural substance, can be used to create tiny particles that effectively deliver various types of drugs, but more work is needed to improve stability and control of drug release.
research Stimulation of Hair Growth by Small Molecules That Activate Autophagy
Certain small molecules can promote hair growth by activating a cellular cleanup process called autophagy.
research Metabolites From Macroalgae and Its Applications in the Cosmetic Industry: A Circular Economy Approach
Macroalgae compounds offer sustainable, effective benefits for cosmetics.
research Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing
PCOS management includes lifestyle changes and medications, with ongoing research into repurposed drugs for better treatment options.
research Advanced Intelligent Systems for Surgical Robotics
Surgical robots have improved but still can't perform tasks or make decisions on their own.
research Specific Citrullination Causes Assembly of a Globular S100A3 Homotetramer
A specific chemical change in the S100A3 protein leads to the formation of a four-part structure important for hair formation.
research Oral Isotretinoin for Acne
Oral isotretinoin may slightly improve acne but increases the risk of side effects like dry lips and skin; more research is needed to understand its full risks and benefits.
research Recent Advances in the Structural Design of Photosensitive Agent Formulations Using Soft Colloidal Nanocarriers
New nanocarriers improve drug delivery for disease treatment.
research Role of Janus Kinase Inhibitors in the Treatment of Alopecia Areata
Janus kinase inhibitors show promise in treating alopecia areata but need better topical formulations.
research Loss of Epidermal Evi/Wls Results in a Phenotype Resembling Psoriasiform Dermatitis
Loss of a specific protein in skin cells causes symptoms similar to psoriasis.
research Spatiotemporal Expression, Distribution, and Processing of POMC and POMC-Derived Peptides in Murine Skin
POMC-derived peptides are important for skin functions like immune response and stress management.
research Progenitor Cell Dysfunctions Underlie Some Diabetic Complications
Diabetes causes lasting cell dysfunctions, leading to serious complications even after blood sugar is controlled.
research CD34 Defines Melanocyte Stem Cell Subpopulations With Distinct Regenerative Properties
CD34+ and CD34- melanocyte stem cells have different regenerative abilities.
research Evolution of Hair Treatment and Care: Prospects of Nanotube-Based Formulations
Nanotube-based hair treatments could improve hair health and growth, and offer long-lasting effects.
research Thymol-Loaded PLGA Nanoparticles: An Efficient Approach for Acne Treatment
Thymol-loaded nanoparticles are a promising, natural treatment for acne that avoids antibiotics and preserves healthy skin bacteria.
research Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome
Changes in the SREBF1 gene cause a rare genetic skin and hair disorder.
research Stem Cells Supporting Other Stem Cells
Stem cells can help other stem cells by producing supportive factors.
research Tyrosinase Depletion Prevents the Maturation of Melanosomes in the Mouse Hair Follicle
Reducing Tyrosinase prevents mature color pigment cells from forming in mouse hair.
research Cutaneous Retinoic Acid Levels Determine Hair Follicle Development And Downgrowth
The right amount of retinoic acid is essential for normal hair growth and development.
research Nanoethosomes for Dermal Delivery of Lidocaine
Nanoethosomes can improve the skin penetration of Lidocaine for topical use.
research Neural Progenitor Cell-Derived Nanovesicles Promote Hair Follicle Growth via miR-100
Tiny particles from brain cells help hair grow by targeting a specific hair growth pathway.
research Pleiotropic Role of Notch Signaling in Human Skin Diseases
Notch signaling disruptions can cause various skin diseases.
research The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but Not for Maintenance of the Epidermal Stem Cell Compartment
Vitamin D Receptor is needed for hair growth in mice but not for skin stem cell maintenance.
research PPAR-γ Signaling as a Key Mediator of Human Hair Follicle Physiology and Pathology
PPAR-γ is important for healthy hair and its problems, and more research on PPAR-γ treatments is needed.