TLDR Oral isotretinoin may slightly improve acne but increases the risk of side effects like dry lips and skin; more research is needed to understand its full risks and benefits.
The document reviewed the efficacy and safety of oral isotretinoin for treating acne, analyzing 31 randomized controlled trials with 3,836 participants. It concluded that isotretinoin was highly effective in reducing severe acne lesions and preventing scarring, but it was associated with significant side effects such as teratogenicity, mucocutaneous effects, elevated liver enzymes, and potential psychiatric symptoms. The review emphasized the importance of closely monitoring patients during treatment to manage these risks effectively. Despite these risks, isotretinoin remained a preferred treatment for severe acne due to its efficacy. The quality of evidence was generally low due to study design limitations and data imprecision, indicating a need for further research.
58 citations,
November 2018 in “Cochrane library” Oral isotretinoin may slightly improve acne but increases the risk of side effects like dry lips and skin; more research is needed to understand its full risks and benefits.
466 citations,
June 2009 in “Experimental dermatology” We now understand more about what causes acne and this could lead to better, more personalized treatments.
117 citations,
January 2003 in “Dermatology” Future acne treatments will be more effective and have fewer side effects.
38 citations,
November 2012 in “Expert Opinion on Drug Safety” Common acne treatments can cause various side effects, like skin irritation and more serious issues, but combination therapies are often more effective and better tolerated.
6 citations,
February 2022 in “JAAD International” Higher doses of isotretinoin may lead to more hair loss.
30 citations,
April 2007 in “Dermatologic Clinics” The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.
21 citations,
June 1990 in “British Journal of Dermatology” Systemic retinoids are effective for psoriasis but have side effects; benefits may outweigh risks, especially when reducing cancer risks from other treatments.
136 citations,
April 2010 in “British Journal of Dermatology” Acitretin is effective for severe skin conditions but has significant side effects and requires careful monitoring.
