July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that impaired Nrf2 signaling and its relationship with keratin 16 may contribute to follicular hyperkeratinization and occlusion in hidradenitis suppurativa, opening new therapeutic avenues.
June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that fibrosis-associated trochanters in central centrifugal cicatricial alopecia are enriched with hair follicle stem cells and may indicate a disrupted stem cell niche contributing to scarring.
31 citations
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September 1996 in “Differentiation” This study claims that the upper dermal sheath of rat vibrissa follicles can induce hair growth under specific conditions, challenging prior beliefs about its lack of inductive capacity.
2 citations
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July 2009 in “Medical hypotheses” This article discusses hair transplant techniques and hypothesizes that smaller regenerating units within hair follicles may allow for one-to-many transplantation, potentially increasing hair numbers for those with hair loss, but reports no new experimental results.
42 citations
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July 2015 in “Drug Development and Industrial Pharmacy” This study concluded that Flutamide-loaded solid lipid nanoparticles may enhance hair follicle drug delivery and promote hair growth in androgenic alopecia compared to a Flutamide hydroalcoholic solution.
January 2017 in “Enlighten: Publications (The University of Glasgow)” This study found that in mice with deregulated β-catenin and PTEN signaling, increased follicular hyperplasia and sebaceous gland changes occur, but typical papillomas do not develop, potentially due to p21 response and reduced stem cell markers.
January 2015 in “SciDok (Saarland University and State Library)” This study confirmed the porcine ear skin model's effectiveness for studying nanoparticle-based drug delivery in human hair follicles, noting particle-dependent uptake and enhancement by massage.
17 citations
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October 2016 in “Artificial Cells Nanomedicine and Biotechnology” This study found that arginine-loaded lipidic nanoparticles improved hair follicle growth in male hamsters more effectively than an aqueous arginine solution.
32 citations
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January 2012 in “Clinical & Developmental Immunology” In this study, rheumatoid arthritis patients showed no changes in the number of circulating follicular helper T cells, but these cells had increased CD200 expression, implicating them in disease pathogenesis and suggesting CD200/CD200R as a potential therapeutic target.
1 citations
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February 2016 in “Cell Transplantation” In this study, researchers found that hair follicles and dermal fibroblasts, including dermal papilla cells, supported sustained hair growth in transplanted murine models, with RNA-seq analysis revealing active signaling pathways and gene expression patterns.
11 citations
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February 2021 in “Biomedicines” This review discusses the role of hair follicle bacterial colonization in immune responses and the pathogenesis of alopecia but reports no new clinical results.
February 2024 in “International journal of pharmaceutical sciences and nanotechnology” In this article, researchers explored the potential of lipidic nanocarriers to enhance the delivery and effectiveness of finasteride in a topical gel form for androgenic alopecia, aiming to improve treatment options and reduce systemic adverse effects.
In this study, a novel liposomal peptide formulation significantly enhanced hair growth in mice compared to minoxidil, but results on human tissue penetration were inconclusive, suggesting further research is needed for translation to human use.
26 citations
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March 1987 in “Journal of the American Academy of Dermatology” This study suggests that topical minoxidil may aid hair regrowth in alopecia areata through synergistic effects on follicular epithelium and lymphocyte-mediated immunological responses, alongside its vasodilatory properties.
March 2024 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that minoxidil nanoparticles significantly increased hair growth in mice compared to commercial minoxidil and rosemary extract, demonstrating improved delivery and follicular uptake.
March 2021 in “Journal of Maxillofacial and Oral Surgery” This case series reports that beard hair can be used effectively as an adjunct donor site for hair transplantation in severe androgenic alopecia, with minimal complications observed.
6 citations
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January 2013 in “Journal of Clinical and Diagnostic Research” This study found that anti-mullerian hormone levels are significantly elevated in infertile women with polycystic ovarian syndrome compared to those with regular cycles, suggesting it as a potential marker for diagnosing PCOS-related infertility.
May 2026 in “International Journal of Molecular Sciences” In this review, researchers explore the roles of lactoferrin in skin and hair health, highlighting its potential anti-inflammatory and regenerative benefits despite the lack of well-controlled clinical trials for hair-specific outcomes.
April 2026 in “Asian Journal of Research in Pharmaceutical Sciences” This review highlights the promising potential of Semecarpus anacardium Linn. in promoting hair growth due to its antioxidant and anti-inflammatory properties but emphasizes the need for further human clinical trials and safe formulation practices due to its associated toxicity in raw form.
February 2026 in “Cureus” This case report suggests that crisaborole may be an effective alternative treatment for alopecia areata in pediatric patients, showing significant hair regrowth after two weeks in a 10-year-old girl.
142 citations
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January 2010 in “Journal of dermatological science” This review covers follicle-targeting drug delivery systems, exploring their potential for improving localized and systemic therapies, and highlights the need for further research into follicle penetration mechanisms.
December 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This mini review discusses insights into the pathogenesis of hidradenitis suppurativa, highlighting genetic mutations, autoinflammation, and the effectiveness of biologics, and introduces the concept of autoinflammatory keratinization disease, without reporting new clinical results.
This study demonstrated that the Biofield Energy Healing Treatment significantly increased the proliferation of human hair follicle dermal papilla cells in vitro, suggesting its potential as a hair growth enhancer.
This abstract discusses the classification of scarring alopecia, distinguishing it from secondary scarring alopecia and detailing its subtypes based on inflammation patterns and cells present during the disease's active phase, but reports no new clinical results.
37 citations
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June 2011 in “Journal of The American Academy of Dermatology” This study demonstrates that sebaceous gland loss is a common early feature in primary scarring alopecia and suggests that inflammation of sebaceous glands or ducts may contribute to follicular damage.
7 citations
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September 2014 in “Beni-Suef University Journal of Basic and Applied Sciences” This study found that ethanolic and petroleum ether extracts of Cuscuta reflexa, as well as an isolate from these extracts, improved hair growth and follicle characteristics in androgen-induced alopecia in rats.
6 citations
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May 2023 in “European journal of pharmaceutical sciences” This study found that niosomes significantly enhanced the skin deposition of retinoic acid while reducing its permeation, outperforming other tested nanoformulations.
5 citations
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January 1999 in “Pediatric Dermatology” This case report presents a young girl with both alopecia areata and immune thrombocytopenic purpura, suggesting a previously unreported association possibly involving cross-reactive antibodies between glycoproteins.
2 citations
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January 2023 in “BioMed Research International” The researchers reported that a 5% Beta vulgaris L. extract nanogel showed better antialopecic activity in testosterone-induced alopecia in mice compared to a 2.5% concentration.
December 2023 in “International Journal of Pharmaceutics” This study developed innovative silica/natural polysaccharide hybrid nanoparticles encapsulating plant-derived 5-alpha-reductase inhibitors, reporting effective controlled release at hair follicle pH and lower cytotoxicity, suggesting a promising delivery system for antiandrogenic treatments.