37 citations
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November 2024 in “Cosmetics” This review examines the promising role of nanocarriers, specifically liposomes and ethosomes, in enhancing transdermal drug delivery for skin diseases. Ethosomes, highlighted for their ability to penetrate deeper skin layers, show potential for more effective treatments but require further clinical investigation.
35 citations
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February 2023 in “Biomolecules” This review explores the role of Granzyme B in autoimmune skin diseases and highlights its potential as a therapeutic target due to its involvement in impaired barrier function and inflammation.
35 citations
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July 2022 in “Frontiers in Integrative Neuroscience” This review discusses the neuroprotective potential of formononetin, especially for neurological diseases, and reports no clinical results; the authors suggest its promise for developing central nervous system drugs.
35 citations
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December 2020 in “International Journal of Molecular Sciences” This review examines the mixed evidence on mast cells as regulators of skin fibrosis and highlights existing gaps in the scientific understanding, reporting no new experimental results.
31 citations
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November 2020 in “International journal of molecular sciences” This review discusses the role of adipokines in skin physiology and pathology, suggesting they may influence skin conditions and diseases through interaction with various skin cell types, but reports no new clinical results.
30 citations
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August 2021 in “Journal of Ethnopharmacology” This review examines the phytochemistry, biological activities, and potential applications of Akebia species in medicine and cosmetology, highlighting the differences in chemical composition between A. quinata and A. trifoliata.
27 citations
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January 2016 in “Cellular Physiology and Biochemistry” This study found that the extract of Bidens pilosa L. improved dry eye symptoms associated with androgen deficiency in rats by enhancing tear production, stabilizing the tear film, and reducing lacrimal gland inflammation.
25 citations
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March 2024 in “Sustainability” This paper discusses strategies for creating sustainable cosmetic emulsions, highlighting the use of food waste, fermentation processes, and low-energy emulsification methods to minimize carbon footprint while preserving the bioactive properties of raw materials.
21 citations
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November 2022 in “Clinical Cosmetic and Investigational Dermatology” This review highlights the potential of several medicinal plants as treatments for seborrhea dermatitis by inhibiting Malassezia growth and reducing symptoms like itching and redness, amid challenges of drug adherence and side effects in existing therapies.
21 citations
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October 2022 in “International Journal of Molecular Sciences” This study found that quercitrin, a natural compound, enhances Wnt/β-catenin signaling and may help mitigate synapse loss and memory impairment in Alzheimer's models.
21 citations
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June 2022 in “Molecules” This review discusses the phytochemistry and pharmacological activities of Perilla frutescens, detailing its bioactive compounds and their potential health benefits, but reports no new clinical results.
19 citations
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March 2023 in “Resources” This review discusses the potential of solid-state fermentation for extracting polyphenolic compounds from agro-industrial wastes, but it reports no new experimental results.
18 citations
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August 2023 in “Journal of Cell Science” This review explores how metabolic changes drive cellular quiescence and considers potential applications in cancer treatment by manipulating these processes.
17 citations
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August 2023 in “Frontiers in Pharmacology” This review highlights the potential of Asteraceae plants as antidiabetic agents and their beneficial effects on conditions such as cardiovascular disease and liver cirrhosis, suggesting their use as food and nutraceuticals could help manage diabetes.
16 citations
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April 2025 in “Foods” This study highlights the diverse applications of *Perilla frutescens* in traditional medicine, cuisine, and industrial settings, noting its significant antioxidant and antimicrobial properties in experimental models, as well as research efforts to enhance its bioactive content and ensure safety and standardization.
16 citations
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October 2023 in “Molecular cancer” This study reviews the etiology and treatment of skin cancer, focusing on nanotechnology's role in addressing drug resistance and evaluating nanoparticles' potential to improve treatment outcomes, including overcoming multidrug resistance.
16 citations
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April 2022 in “Journal of Food Quality” This study found that blueberry waste in Australia has high phenolic content and antioxidant potential, suggesting potential uses in food, pharmaceutical, and nutraceutical industries.
13 citations
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January 2023 in “Frontiers in Nutrition” This review explored the chemical makeup and pharmacological effects of Lindera aggregata, identifying 349 components including sesquiterpenoids, flavonoids, and alkaloids, with various potential benefits demonstrated in vitro and in vivo, such as anti-inflammatory and antioxidant effects.
12 citations
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June 2024 in “Nutrients” In this review, researchers highlighted that natural polyphenolics like flavonoids and resveratrol may help enhance testosterone production in aging males by boosting the expression of the Star gene in Leydig cells, potentially preventing age-related degenerative conditions linked to testosterone insufficiency.
12 citations
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December 2023 in “Antioxidants” In this study, researchers found that blackberry leaves exhibited higher liposoluble antioxidant levels and inhibited lipid peroxidation more effectively than raspberry leaves, while raspberry leaves showed greater water-soluble antioxidant content and hydroxyl radical inhibition in vitro.
12 citations
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March 2022 in “Antioxidants” This study found that encapsulating tamarillo polyphenols in cubosome nanoparticles protected them during digestion and enhanced the nutritional and antioxidant properties of yoghurt when used as a delivery system.
10 citations
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August 2024 in “ACS Omega” This review discusses the use of nanomaterials in cosmetics, highlighting their benefits like enhanced stability and skin penetration, while also noting potential health risks and the role of natural ingredients in formulations.
10 citations
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April 2022 in “Frontiers in Genetics” This study identified and analyzed 88 MYB genes in Curcuma wenyujin, finding that specific genes are significantly induced by cold, NaCl, and MeJA stress treatments, which suggests their role in stress response mechanisms.
9 citations
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June 2023 in “Cells” This review summarizes recent findings on how the dysregulated PI3K/Akt/mTOR pathway contributes to immune-mediated inflammatory skin disorders and discusses the potential of natural products, synthetic compounds, and biologic agents in their treatment. However, it emphasizes the need for further research to develop effective therapies.
9 citations
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December 2022 in “Phytomedicine” This review discusses the pharmacology, toxicology, and clinical efficacy of flavonoids and saponins, highlighting the need for more data on their pharmacokinetics, interactions, and toxicities as most research is still in vitro.
9 citations
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November 2022 in “Applied sciences” This review explores marine algae-derived phenolic compounds and their potential cosmeceutical benefits, but reports no new clinical results.
9 citations
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June 2022 in “Microorganisms” This review outlines the urgent need for effective therapeutic interventions against coronaviruses, as current vaccines are challenged by virus mutations, and emphasizes developing safe, affordable, and broad-spectrum antivirals for both human and porcine coronaviruses.
9 citations
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June 2022 in “Reviews in Environmental Science and Bio/Technology” This review discusses the industrial applications of maritime pine by-products, emphasizing their antioxidant and antimicrobial properties, and suggests innovation opportunities in a circular economy context; it reports no new results.
9 citations
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May 2014 in “Clinical Cosmetic and Investigational Dermatology” This study suggests that combining GliSODin(®) Skin Nutrients with tazarotene cream significantly benefits facial fine wrinkles, photodamage, moisture, and elasticity compared to tazarotene alone.
8 citations
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February 2025 in “Pharmaceuticals” This source reviews the potential of polyphenols as therapeutic and preventive treatments for common skin disorders such as acne, fungal infections, dermatitis, alopecia, and skin cancer, emphasizing their anti-inflammatory and antimicrobial effects and ability to penetrate the skin barrier.