A Review of the Evidence for and Against a Role for Mast Cells in Cutaneous Scarring and Fibrosis

    Traci A. Wilgus, Sara Ud‐Din, Ardeshir Bayat
    TLDR Mast cells likely promote skin scarring and fibrosis, but their exact role is still unclear.
    The review examined the role of mast cells in cutaneous scarring and fibrosis, presenting evidence both for and against their involvement. Mast cells were found to contribute to fibrosis by releasing mediators like TGF-β, chymase, and tryptase, which promote fibroblast proliferation and collagen synthesis. However, some studies indicated that mast cells might not be essential for wound healing or fibrosis, as genetic ablation did not significantly impair these processes in certain models. The review highlighted the complexity and context-dependency of mast cell functions, suggesting that their role in fibrosis varies with different types of wounds and healing environments. Further research was needed to fully understand their interactions and potential as therapeutic targets.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 29 results

      community Hair Loss & Lipids: Why you have sebderm, folliculitis, LPP, inflammation, etc...

      in Research/Science  131 upvotes 2 weeks ago
      Excess sebum rich in cholesterol and triglycerides can lead to hair loss through inflammation, with treatments like Ciclopirox shampoo, Benzoyl Peroxide shampoo, and Clindamycin gel recommended for managing conditions like seborrheic dermatitis and folliculitis. Pioglitazone is suggested for Lichen Planopilaris, while Omega-3s and reducing processed foods may improve sebum quality, though genetic factors play a significant role.

      community A hill on which I will die: The DHT itch absolutely exists

      in Research/Science  208 upvotes 10 months ago
      The DHT itch is linked to hair loss and persists despite finasteride use; switching to dutasteride helped alleviate the itch and promoted regrowth. Some users suggest seborrheic dermatitis as a cause and recommend treatments like medicated shampoos, vitamin D, and minoxidil.

      community Is the DHT itch fact or fiction?

      in Chat  16 upvotes 1 year ago
      DHT itch's existence is debated, with some claiming it's real and others saying it's psychological. Finasteride, Ketoconazole shampoo, and addressing scalp conditions like dandruff or eczema may help reduce itchiness.

      community Pyrilutamide cease and desist from Kintor

      in Transplants  12 upvotes 1 year ago
      Considering a hair transplant, using Pyrilutamide, the potential availability of CosmeRNA, and the significance of taking Minoxidil and Finasteride for long-term results.

      community Dutasteride Vs. Testosterone, who wins?

      in Finasteride/Dutasteride  58 upvotes 11 months ago
      The conversation discusses whether 2.5mg of dutasteride or 200mg of testosterone weekly is more influential in preventing hair loss, with various personal experiences indicating that the effectiveness is dependent on the individual's genetic profile. Some users report that dutasteride is likely to be more effective at the given doses.

    Similar Research

    5 / 1000+ results