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This article reviews the pathogenesis of frontal fibrosing alopecia, highlighting the potential genetic and environmental contributions, particularly the use of sunscreens, and calls for further research into effective treatments.

Some drugs for inflammation may cause psoriasis-like hair loss.

This case report describes a 21-year-old male diagnosed with Crohn's disease and ulcerative pyoderma gangrenosum presenting with diverse extraintestinal symptoms, and highlights the success of a multi-drug treatment regimen including steroids and infliximab in improving clinical outcomes, though hematochezia was initially persistent.

This case report describes a 46-year-old man diagnosed with frontal fibrosing alopecia, a condition primarily affecting postmenopausal women, highlighting its rare occurrence in men.

This case report describes a young man with rapidly progressive cicatricial alopecia that shows features overlapping several other types, suggesting these conditions may exist on a spectrum.

In this study, HPH-15, a newly synthesized compound, demonstrated potential in reducing skin fibrosis in a mouse model by targeting underlying pathogenic mechanisms and exhibited a good safety profile, warranting further clinical trials for fibrotic skin disorders like systemic sclerosis.

This study found that Annexin A5 significantly reduced fibrosis and inflammation in both preventive and therapeutic contexts in a bleomycin-induced localized scleroderma mouse model, demonstrating its potential anti-fibrotic and anti-inflammatory effects for treating fibrotic diseases.

This study found that patients with mycosis fungoides have higher levels of cardiovascular risk markers, suggesting an increased cardiovascular risk in this group compared to healthy controls.

This case report details a 56-year-old woman's diagnosis with an overlapping syndrome of dermatomyositis, systemic lupus, and secondary antiphospholipid syndrome, highlighted by purpura fulminans, treated successfully with immunosuppressants and plasmapheresis.

This study reports an association between frontal fibrosing alopecia and lupus erythematosus, noting progressive alopecia in the frontotemporal hairline despite treatment with hydroxychloroquine.

This review explores the complex role of the Innate Immune System in rheumatoid arthritis, highlighting gaps in understanding its functions and interactions with the Adaptive Immune System, offering insights into potential biomarkers and therapeutic strategies for this challenging autoimmune condition.

This study observed that some children and young adults with alopecia areata experienced flares during long-term tofacitinib treatment, despite initial successful hair regrowth.

In this case report, a woman in her 50s was diagnosed with meningitis linked to mixed connective tissue disease after presenting symptoms similar to infectious meningitis, but with no infection detected and serological evidence pointing to the autoimmune condition.

This study found that the protein Fetuin A, when injected into fetal wounds that typically heal without scarring, caused scar formation and increased collagen production in fibroblasts in an animal model.

This review highlights that frontal fibrosing alopecia’s increasing incidence may involve immune, genetic, hormonal, and environmental factors, yet its pathogenesis remains complex and not fully understood.

This study found that in patients with elevated fibrinogen levels undergoing revision rhinoplasty, PDRN decreased M1 cytokines and increased M2 cytokines, potentially offering a new therapeutic approach, but further research is needed to understand its mechanisms and effects fully.

This review discusses fibrosing frontal alopecia, including its causes, mechanisms, and treatments, and emphasizes the need for further research to improve understanding and treatments; it reports no new clinical results.

This study found that fibromyalgia prevalence is slightly higher in patients with systemic lupus erythematosus compared to those with arthritis, but fibromyalgia-ness does not bias the SLE Activity Questionnaire.

In this study, intralesional triamcinolone acetonide injections were associated with halting the progression of frontal fibrosing alopecia in female patients and showed minimal adverse effects, but the efficacy as sole therapy remains unclear pending further trials.

This article presents a case study of a 50-year-old woman with frontal fibrosing alopecia and discusses the role of dermoscopy in differentiating it from other types of alopecia, reporting no new clinical results.

Infliximab may cause hair loss in Crohn's disease patients.

This report describes a case where a woman with frontal fibrosing alopecia initially presented with symptoms resembling rosacea, but further investigation led to a diagnosis of FFA, resulting in a treatment change to oral finasteride and hydroxychloroquine.

Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.

This review discusses fibrosing alopecia in a pattern distribution and highlights diagnostic features, but reports no new clinical results; the authors emphasize the value of trichoscopy and histology in diagnosis.

In this study, FN-based fiber scaffolds designed using Rotary Jet-Spinning were shown to enhance wound healing and reduce scar formation in a mouse model, suggesting potential for regenerating healthy skin structure.

This review suggests that excessive facial photoprotection could play a role in frontal fibrosing alopecia through a disturbance in immunological balance via the aryl hydrocarbon receptor-kynurenine pathway.

This study found that a novel skin patch combining extracellular matrix and ciprofloxacin promotes advanced wound healing and skin regeneration in mouse models of infected wounds.

In this review study, systemic isotretinoin emerged as the most effective treatment for dissecting cellulitis of the scalp, while biologics and JAK inhibitors showed promise for resistant cases, and procedural methods were used in severe stages; however, controlled studies are needed for developing clinical guidelines.

This review discusses the enigmatic nature of frontal fibrosing alopecia and reports no clinical results; the authors stress the need for further research.