Rapidly Progressive Diffuse Fibrosing Alopecia

October 2019 in “ JAAD Case Reports ”

Xufeng Du, Zhongming Li, Qilin Zhu, Wengrong Xu, Yuqian Li, Jing Zhu, Dirk M. Elston

cicatricial alopecia frontal fibrosing alopecia lichen planopilaris fibrosing alopecia with a pattern distribution cicatricial pattern hair loss

TLDR These hair loss conditions might be part of a spectrum, not separate issues.

The document described a case of rapidly progressive diffuse fibrosing alopecia in a 25-year-old man, characterized by overlapping features of frontal fibrosing alopecia (FFA), lichen planopilaris (LPP), fibrosing alopecia with a pattern distribution (FAPD), and cicatricial pattern hair loss (CPHL). The patient exhibited significant hair thinning and small patches of hair loss across the scalp, with histopathologic findings of lichenoid folliculitis and concentric fibrosis. Treatment included oral glycyrrhizin, topical tacrolimus, and halometasone, with subsequent stabilization and eyebrow regrowth. The study suggested that these conditions might exist along a spectrum, with diffuse fibrosing alopecia representing a widespread form. Further research was needed to clarify the pathogenesis and distinctions between these overlapping alopecia subtypes.

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Research cited in this study

7 / 7 results

Treatment of Male Pattern Alopecia with Platelet-Rich Plasma: A Double-Blind Controlled Study with Analysis of Platelet Number and Growth Factor Levels

research Treatment of Male Pattern Alopecia with Platelet-Rich Plasma: A Double-Blind Controlled Study with Analysis of Platelet Number and Growth Factor Levels

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Graft Versus Host Disease Presenting as Fibrosing Alopecia in a Pattern Distribution: A Model for Pathophysiological Understanding of Cicatricial Pattern Hair Loss

research Graft Versus Host Disease Presenting as Fibrosing Alopecia in a Pattern Distribution: A Model for Pathophysiological Understanding of Cicatricial Pattern Hair Loss

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Is There a Pathogenetic Link Between Frontal Fibrosing Alopecia, Androgenetic Alopecia, and Fibrosing Alopecia in a Pattern Distribution?

research Is There a Pathogenetic Link Between Frontal Fibrosing Alopecia, Androgenetic Alopecia, and Fibrosing Alopecia in a Pattern Distribution?

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Frontal fibrosing alopecia and androgenetic alopecia may be related, with a possible shared cause.

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5 citations , February 2017 in “Australasian Journal of Dermatology”

Scarring hair loss found in female pattern; biopsy needed for diagnosis.

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research Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche

220 citations , June 2013 in “The Journal of Pathology”

Lichen planopilaris may be an autoimmune disease causing hair loss due to immune system issues in hair follicles.

research Female Pattern Hair Loss and Its Relationship to Permanent/Cicatricial Alopecia: A New Perspective

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Some women with common hair loss may develop permanent hair loss.

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Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

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The user is experiencing hair loss and confusion over conflicting medical advice, with treatments including minoxidil, finasteride, and topical corticosteroids. They are unsure about the necessity of a biopsy and the timing of using minoxidil, while also considering the impact of potential androgenetic alopecia and telogen effluvium.

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