Frontal Fibrosing Alopecia: An Example of Disrupted Aryl Hydrocarbon Receptor-Mediated Immunological Homeostasis in the Skin?

    July 2020 in “ DOAJ (DOAJ: Directory of Open Access Journals) ”
    Noakes R
    TLDR Excessive sun protection might contribute to frontal fibrosing alopecia.
    The document discussed the hypothesis that frontal fibrosing alopecia (FFA), a type of scarring hair loss, might have been linked to excessive facial photoprotection. This excessive protection could have disrupted immunological homeostasis through the aryl hydrocarbon receptor-kynurenine pathway axis (AHR/KP), potentially leading to the collapse of immune privilege at the hair bulge. The review highlighted the balance needed between sun protection to prevent skin tumors and the necessity of some sun exposure for vitamin D synthesis.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 663 results

      community can someone help me identify these pls

      in Treatment 3 months ago
      The user is experiencing diffuse thinning and inflammation despite using 2.5mg dutasteride daily, ciclopirox, and ketoconazole shampoos. They are considering treatments like hydroxychloroquine and JAK inhibitors due to suspected scarring alopecia and have faced challenges in obtaining a scalp biopsy.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Fibrosing alopecia in a pattern distribution

      in Research/Science  14 upvotes 1 year ago
      A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

      community I think I’ve finally found the reason for my hair loss

      in Chat  98 upvotes 1 year ago
      The user experienced hair loss since 2019 and tried finasteride, dutasteride, RU58841, and ketoconazole shampoo without success. A scalp biopsy showed scarring and inflammation from folliculitis, indicating chronic inflammation was affecting treatment effectiveness.

    Similar Research

    5 / 1000+ results