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This review explores the potential diagnostic and therapeutic applications of extracellular vesicles in treating various skin conditions but reports no new clinical study results.

A rare skin condition causes red and dark patches on the face and limbs.

In a mouse model of chemotherapy-induced alopecia, this study found that enhancing ETV2 expression improved angiogenesis and hair regrowth following 5-fluorouracil treatment.

This study found no persistent presence of Coxsackie virus genome in the skin of pemphigus patients despite higher IgG positivity compared to controls, suggesting the need for larger studies to clarify its role.

In this study, IFN-γ-stimulated iPSC-derived mesenchymal stem cell extracellular vesicles improved atopic dermatitis in mice by reducing Th2 cytokine activity, suppressing inflammation, and restoring skin barrier function, as evidenced by decreased itching and inflammatory markers.

This study found that a wound dressing made from egg white proteins, polyvinyl alcohol, and 1 mg/ml graphene oxide was most effective in promoting skin wound healing and tissue regeneration.

This study found that tdDPC-EVs significantly improved wound healing by enhancing angiogenesis through the KLF4/VEGFA axis, offering advantages over traditional DPC-EVs.

This study found that epidermal growth factor receptor inhibitors can induce erosive pustular dermatosis of the scalp, typically appearing sooner and affecting the scalp more extensively compared to other triggers.

This study found that scanning electron microscopy with argon sputter etching visualizes hair lipids at the cell membrane complex as distinctive convex structures, shedding light on their role and localization in human hair.

In this study, PGD2 was shown to increase testosterone production in human keratinocytes through reactive oxygen species, suggesting potential benefits of antioxidants like N-acetyl-cysteine for AGA patients.

This study reports that EGF at specific concentrations promotes the proliferation and migration of hair follicle ORS cells by activating the Wnt/β-catenin signaling pathway in vitro.

This study found that the RapidHIT™ ID system can successfully obtain DNA profiles from single hair roots, particularly those with high nuclei counts.

This study found that exogenous EGF inhibited hair follicle development and decreased follicle density in both Tabby and normal mice, suggesting interactions between EGF and the Ta peptide influence normal skin phenotype.

This review highlights the potential of extracellular vesicle-based therapies for treating various diseases, but it also notes challenges like the lack of regulatory guidelines that hinder their clinical development.

This study observed that recognizing herpetic infection in pemphigus patients can help avoid unnecessary changes in immunosuppressive treatments for lesions wrongly presumed treatment-resistant.

In this study, researchers analyzed 355 clinical trials from ClinicalTrials.gov, initiated by the end of 2025, to provide insights into the use of extracellular vesicles as circulating biomarkers or therapeutic interventions, highlighting current research priorities and future trends.

This report presents a case of molluscum contagiosum virus infection within an epidermoid cyst in a 13-year-old on long-term steroid treatment, highlighting its rare occurrence and need for histological examination for accurate diagnosis.

This study describes a gel-supported in vitro system for culturing skin samples that may effectively replace animal systems for toxicity testing, showing high correlation with in vivo skin toxicity measurements.

This study suggests that eruptive vellus hair cysts often have atypical pathological changes and likely originate from the infrainfundibulum and sebaceous duct based on keratin expression analysis.

Patients often experience long-lasting changes to their hair after stem cell transplants.

In this study, prenatal ultrasonography was found to be a valuable tool for screening ectodermal dysplasia during pregnancy, and a new EDA gene variant associated with X-linked hypohidrotic ectodermal dysplasia was identified, aiding in more accurate diagnoses and reproductive decision-making.

This case study and literature review describe eruptive vellus hair cysts as uncommon, potentially inherited or acquired lesions, associated with other skin conditions, and challenging to treat despite being benign.

This study found that using poly(ethylene imine) as a counterion reagent improved the colorability and shampoo fastness of bleached human hair when dyed with an acid dye.

This study reports a novel mutation in the TP63 gene associated with T and B cell lymphopenia in an EEC patient, suggesting that EEC diagnosis should include TREC assay and evaluation for immunodeficiency.

This review discusses how extracellular vesicles play a dual role in age-related diseases by contributing to both disease pathogenesis and potential therapeutic strategies through the transfer of specific molecules.

This study observed that Nod factor stimulation in alfalfa roots leads to dynamic changes in the cytoskeleton and endoplasmic reticulum, suggesting a mechanism for root hair growth changes.

This study found that adipose-derived stem cell extracellular vesicles reduced wrinkles and promoted cell proliferation in UVB-induced photoaging in mice by decreasing oxidative stress and inflammation.

This study found that combining weekly transverse needling sessions with mini-punch grafting significantly accelerated and enhanced repigmentation in stable, resistant non-segmental vitiligo lesions compared to each procedure alone or non-procedural treatment.