The Global Clinical Landscape of Human-Derived Extracellular Vesicles: An Analysis Based on ClinicalTrials.gov (2010–2025)

    March 2026 in “ Clinical and Experimental Medicine ”
    Wenjuan Wei, Ximeng Wu, Lizhi Wang, Yanqiu Yu, Liusong Yang, Chan Zhang, Daqing Wang
    TLDR Extracellular vesicles are important for disease treatment and monitoring.
    Extracellular vesicles (EVs) have significantly impacted disease exploration and treatment by precisely regulating the cellular microenvironment. An analysis of 355 clinical trials from ClinicalTrials.gov, initiated by the end of 2025, highlights the use of EVs as circulating biomarkers or therapeutic interventions across various diseases. This study offers a comprehensive overview of these trials, emphasizing important research priorities and future trends in the field, which are crucial for academic research, disease monitoring, and biopharmaceutical advancements.
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