Global Research Trends in Extracellular Vesicle-Based Therapy for Regenerative Medicine: A Bibliometric Analysis (2014–2024)

The document analyzes global research trends in extracellular vesicle (EV)-based therapy for regenerative medicine from 2014 to 2024, noting significant growth in the field. EVs are highlighted as promising alternatives to traditional stem cell therapies due to their stability, lower costs, and reduced immunogenicity. China leads in publication volume, while the USA dominates citation impact. Key journals include "Stem Cell Research & Therapy" and "International Journal of Molecular Sciences." The study identifies thematic clusters like oxidative stress and muscle regeneration, with a strategic shift toward engineered EVs and novel sources such as iPSCs. Despite advancements, challenges like standardization, scalability, and regulatory issues remain, which are crucial to address for clinical application. The field's maturity is underscored by the convergence of diverse disciplines and international collaboration.